TY - JOUR
T1 - Untapped potential of observational research to inform clinical decision making
T2 - American Society of Clinical Oncology Research statement
AU - Visvanathan, Kala
AU - Levit, Laura A.
AU - Raghavan, Derek
AU - Hudis, Clifford A.
AU - Wong, Sandra
AU - Dueck, Amylou
AU - Lyman, Gary H.
N1 - Publisher Copyright:
© 2017 American Society of Clinical Oncology.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - ASCO believes that high-quality observational studies can advance evidence-based practice for cancer care and are complementary to randomized controlled trials (RCTs). Observational studies can generate hypotheses by evaluating novel exposures or biomarkers and by revealing patterns of care and relationships that might not otherwise be discovered. Researchers can then test these hypotheses in RCTs. Observational studies can also answer or inform questions that either have not been or cannot be answered by RCTs. In addition, observational studies can be used for postmarketing surveillance of new cancer treatments, particularly in vulnerable populations. The incorporation of observational research as part of clinical decision making is consistent with the position of many leading institutions. ASCO identified five overarching recommendations to enhance the role of observational research in clinical decision making: (1) improve the quality of electronic health data available for research, (2) improve interoperability and the exchange of electronic health information, (3) ensure the use of rigorous observational research methodologies, (4) promote transparent reporting of observational research studies, and (5) protect patient privacy.
AB - ASCO believes that high-quality observational studies can advance evidence-based practice for cancer care and are complementary to randomized controlled trials (RCTs). Observational studies can generate hypotheses by evaluating novel exposures or biomarkers and by revealing patterns of care and relationships that might not otherwise be discovered. Researchers can then test these hypotheses in RCTs. Observational studies can also answer or inform questions that either have not been or cannot be answered by RCTs. In addition, observational studies can be used for postmarketing surveillance of new cancer treatments, particularly in vulnerable populations. The incorporation of observational research as part of clinical decision making is consistent with the position of many leading institutions. ASCO identified five overarching recommendations to enhance the role of observational research in clinical decision making: (1) improve the quality of electronic health data available for research, (2) improve interoperability and the exchange of electronic health information, (3) ensure the use of rigorous observational research methodologies, (4) promote transparent reporting of observational research studies, and (5) protect patient privacy.
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U2 - 10.1200/JCO.2017.72.6414
DO - 10.1200/JCO.2017.72.6414
M3 - Article
C2 - 28358653
AN - SCOPUS:85022342472
SN - 0732-183X
VL - 35
SP - 1845
EP - 1854
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 16
ER -