Unsupervised deconvolution of dynamic imaging reveals intratumor vascular heterogeneity and repopulation dynamics

Li Chen, Peter L. Choyke, Niya Wang, Robert Clarke, Zaver M Bhujwalla, Elizabeth M C Hillman, Ge Wang, Yue Wang

Research output: Contribution to journalArticle

Abstract

With the existence of biologically distinctive malignant cells originated within the same tumor, intratumor functional heterogeneity is present in many cancers and is often manifested by the intermingled vascular compartments with distinct pharmacokinetics. However, intratumor vascular heterogeneity cannot be resolved directly by most in vivo dynamic imaging. We developed multi-tissue compartment modeling (MTCM), a completely unsupervised method of deconvoluting dynamic imaging series from heterogeneous tumors that can improve vascular characterization in many biological contexts. Applying MTCM to dynamic contrast-enhanced magnetic resonance imaging of breast cancers revealed characteristic intratumor vascular heterogeneity and therapeutic responses that were otherwise undetectable. MTCM is readily applicable to other dynamic imaging modalities for studying intratumor functional and phenotypic heterogeneity, together with a variety of foreseeable applications in the clinic.

Original languageEnglish (US)
Article numbere112143
JournalPLoS One
Volume9
Issue number11
DOIs
StatePublished - Nov 7 2014

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Deconvolution
blood vessels
Blood Vessels
image analysis
Imaging techniques
Tissue
neoplasms
Tumors
Neoplasms
Pharmacokinetics
Magnetic resonance
magnetic resonance imaging
breast neoplasms
pharmacokinetics
Magnetic Resonance Imaging
Breast Neoplasms
therapeutics
tissues
cells
Therapeutics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Unsupervised deconvolution of dynamic imaging reveals intratumor vascular heterogeneity and repopulation dynamics. / Chen, Li; Choyke, Peter L.; Wang, Niya; Clarke, Robert; Bhujwalla, Zaver M; Hillman, Elizabeth M C; Wang, Ge; Wang, Yue.

In: PLoS One, Vol. 9, No. 11, e112143, 07.11.2014.

Research output: Contribution to journalArticle

Chen, Li ; Choyke, Peter L. ; Wang, Niya ; Clarke, Robert ; Bhujwalla, Zaver M ; Hillman, Elizabeth M C ; Wang, Ge ; Wang, Yue. / Unsupervised deconvolution of dynamic imaging reveals intratumor vascular heterogeneity and repopulation dynamics. In: PLoS One. 2014 ; Vol. 9, No. 11.
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