Unresolved questions from the analysis of mice lacking MCU expression

Elizabeth Murphy, Xin Pan, Tiffany Nguyen, Jie Liu, Kira M. Holmström, Toren Finkel

Research output: Contribution to journalArticle

Abstract

Entry of mitochondrial calcium is believed to play an essential role in regulating bioenergetics and initiating cell death pathways. We have recently described a mouse model lacking MCU expression. Surprisingly, these mice are viable and the cells and tissues from these animals do not exhibit any marked protection from cell death. Here, we discuss our findings as well as potential explanations for some of the more unexpected results.

Original languageEnglish (US)
Pages (from-to)384-385
Number of pages2
JournalBiochemical and Biophysical Research Communications
Volume449
Issue number4
DOIs
StatePublished - 2014
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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