Unraveling the molecular pathways of DNA-methylation inhibitors: Human endogenous retroviruses induce the innate immune response in tumors

Reiner Strick; Pamela L. Strissel; Stephen B. Baylin; Katherine B. Chiappinelli

doi:10.1080/2162402X.2015.1122160

Unraveling the molecular pathways of DNA-methylation inhibitors: Human endogenous retroviruses induce the innate immune response in tumors

Reiner Strick, Pamela L. Strissel, Stephen B. Baylin, Katherine B. Chiappinelli

School of Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockage of immune checkpoint proteins to fight cancer.

Original language	English (US)
Article number	e1122160
Journal	OncoImmunology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1080/2162402X.2015.1122160
State	Published - May 3 2016

Keywords

DNA methylation
Endogeneous retrovirus (ERV)
Epigenetic therapy
IFN-signalling
Immune checkpoints
Innate immunity
TLR
dsRNA

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.1080/2162402X.2015.1122160

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title = "Unraveling the molecular pathways of DNA-methylation inhibitors: Human endogenous retroviruses induce the innate immune response in tumors",

abstract = "Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockage of immune checkpoint proteins to fight cancer.",

keywords = "DNA methylation, Endogeneous retrovirus (ERV), Epigenetic therapy, IFN-signalling, Immune checkpoints, Innate immunity, TLR, dsRNA",

author = "Reiner Strick and Strissel, {Pamela L.} and Baylin, {Stephen B.} and Chiappinelli, {Katherine B.}",

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AU - Chiappinelli, Katherine B.

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KW - IFN-signalling

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KW - TLR

KW - dsRNA

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Unraveling the molecular pathways of DNA-methylation inhibitors: Human endogenous retroviruses induce the innate immune response in tumors

Abstract

Keywords

ASJC Scopus subject areas

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