Unraveling the molecular pathways of DNA-methylation inhibitors: Human endogenous retroviruses induce the innate immune response in tumors

Reiner Strick, Pamela L. Strissel, Stephen B. Baylin, Katherine B. Chiappinelli

Research output: Contribution to journalArticlepeer-review

Abstract

Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockage of immune checkpoint proteins to fight cancer.

Original languageEnglish (US)
Article numbere1122160
JournalOncoImmunology
Volume5
Issue number5
DOIs
StatePublished - May 3 2016

Keywords

  • DNA methylation
  • Endogeneous retrovirus (ERV)
  • Epigenetic therapy
  • IFN-signalling
  • Immune checkpoints
  • Innate immunity
  • TLR
  • dsRNA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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