Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors

Reiner Strick, Pamela L. Strissel, Stephen B Baylin, Katherine B. Chiappinelli

Research output: Contribution to journalArticle

Abstract

Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockage of immune checkpoint proteins to fight cancer.

Original languageEnglish (US)
JournalOncoImmunology
DOIs
StateAccepted/In press - Apr 25 2016

Keywords

  • dsRNA
  • IFN-signalling
  • immune checkpoints
  • DNA methylation
  • endogeneous retrovirus (ERV)
  • epigenetic therapy
  • innate immunity
  • TLR

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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