Abstract
Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockage of immune checkpoint proteins to fight cancer.
Original language | English (US) |
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Article number | e1122160 |
Journal | OncoImmunology |
Volume | 5 |
Issue number | 5 |
DOIs | |
State | Published - May 3 2016 |
Keywords
- DNA methylation
- Endogeneous retrovirus (ERV)
- Epigenetic therapy
- IFN-signalling
- Immune checkpoints
- Innate immunity
- TLR
- dsRNA
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology