Unraveling the early steps of prokaryotic replication

Erin L. Cunningham, James M. Berger

Research output: Contribution to journalReview articlepeer-review


In prokaryotes, many of the physical mechanisms governing the process of initiating DNA replication are now emerging. For example, certain organizational features of origins, such as the use of repetitive sequence elements for initiator-binding sites, are found throughout bacteria and many archaea. Common themes in the regulation of initiation, including origin sequestration by trans-acting factors, titration of initiator levels by cis- and trans-acting factors, and control of initiator function by ATP, also exist. Recent studies have shown that prokaryotic initiator structures are both modular and conserved, and have begun to reveal how these proteins specifically recognize target DNA sequences. These properties probably control initiator self-assembly and DNA remodeling to properly fire replication origins.

Original languageEnglish (US)
Pages (from-to)68-76
Number of pages9
JournalCurrent Opinion in Structural Biology
Issue number1 SPEC. ISS.
StatePublished - Feb 2005
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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