Unmet medical needs in systemic lupus erythematosus

Aisha Lateef, Michelle Petri

Research output: Contribution to journalArticle

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease of diverse manifestations, with onset usually in young women in the third to fourth decade of life. The chronic nature of this relapsing remitting disease leads to organ damage accrual over time. Mortality and morbidity are increased in patients with SLE compared with the general population. Therapeutic advances over the last few decades have led to significant improvements in patient outcomes. Five-year survival has improved to over 90% from a low of 50% in the 1950s. However, multiple aspects of the management of SLE patients are still far from optimal. Early diagnosis remains a challenge; diagnostic delays leading to delay in definitive treatment are common. Monitoring treatment remains problematic due to the paucity of sensitive biomarkers. Current treatment regimens rely heavily on corticosteroids, even though corticosteroids are well known to cause organ damage. Treatment of refractory disease manifestations such as nephritis, recalcitrant cutaneous lesions and neurological involvement require new approaches with greater efficacy. Cognitive dysfunction is common in SLE patients, but early recognition and adequate treatment are yet to be established. Premature accelerated atherosclerosis remains a leading cause of morbidity and mortality. Fatigue is one of the most disabling symptoms, and contributes to the poor quality of life in patients with SLE. Ongoing research in SLE faces many challenges, including enrollment of homogeneous patient populations, use of reliable outcome measures and a standard control arm. The current review will highlight some of the outstanding unmet challenges in the management of this complex disease.

Original languageEnglish (US)
Article numberS4
JournalArthritis Research and Therapy
Volume14
Issue numberSUPPL. 4
DOIs
StatePublished - Dec 18 2012

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Systemic Lupus Erythematosus
Adrenal Cortex Hormones
Therapeutics
Morbidity
Mortality
Nephritis
Disease Management
Population
Autoimmune Diseases
Fatigue
Early Diagnosis
Atherosclerosis
Biomarkers
Quality of Life
Outcome Assessment (Health Care)
Skin
Survival
Research

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Unmet medical needs in systemic lupus erythematosus. / Lateef, Aisha; Petri, Michelle.

In: Arthritis Research and Therapy, Vol. 14, No. SUPPL. 4, S4, 18.12.2012.

Research output: Contribution to journalArticle

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