Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade

Research output: Contribution to journalArticle

Abstract

Focal tumor cell PD-L1 expression adjacent to TIL can be used as a surrogate marker of an ongoing antitumor host response, which may be unleashed by PD-1 blockade. Tumor cell PD-L1 expression is superior to TIL PD-1 expression and the presence of TIL alone, when predicting response to anti-PD-1 therapy.

Original languageEnglish (US)
Pages (from-to)e963413-1-e963413-3
JournalOncoImmunology
Volume3
Issue number11
DOIs
StatePublished - Nov 2 2014

Fingerprint

Tumor Microenvironment
Immune System
Neoplasms
Biomarkers
Therapeutics

Keywords

  • cancer immunotherapy
  • PD-1
  • PD-L1
  • PD-L2
  • tumor microenvironment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

Unleashing the immune system : PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade. / Taube, Janis M.

In: OncoImmunology, Vol. 3, No. 11, 02.11.2014, p. e963413-1-e963413-3.

Research output: Contribution to journalArticle

@article{7f09385bb0a044d3b859b105d7902128,
title = "Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade",
abstract = "Focal tumor cell PD-L1 expression adjacent to TIL can be used as a surrogate marker of an ongoing antitumor host response, which may be unleashed by PD-1 blockade. Tumor cell PD-L1 expression is superior to TIL PD-1 expression and the presence of TIL alone, when predicting response to anti-PD-1 therapy.",
keywords = "cancer immunotherapy, PD-1, PD-L1, PD-L2, tumor microenvironment",
author = "Taube, {Janis M}",
year = "2014",
month = "11",
day = "2",
doi = "10.4161/21624011.2014.963413",
language = "English (US)",
volume = "3",
pages = "e963413--1--e963413--3",
journal = "OncoImmunology",
issn = "2162-4011",
publisher = "Landes Bioscience",
number = "11",

}

TY - JOUR

T1 - Unleashing the immune system

T2 - PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade

AU - Taube, Janis M

PY - 2014/11/2

Y1 - 2014/11/2

N2 - Focal tumor cell PD-L1 expression adjacent to TIL can be used as a surrogate marker of an ongoing antitumor host response, which may be unleashed by PD-1 blockade. Tumor cell PD-L1 expression is superior to TIL PD-1 expression and the presence of TIL alone, when predicting response to anti-PD-1 therapy.

AB - Focal tumor cell PD-L1 expression adjacent to TIL can be used as a surrogate marker of an ongoing antitumor host response, which may be unleashed by PD-1 blockade. Tumor cell PD-L1 expression is superior to TIL PD-1 expression and the presence of TIL alone, when predicting response to anti-PD-1 therapy.

KW - cancer immunotherapy

KW - PD-1

KW - PD-L1

KW - PD-L2

KW - tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=84938631461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938631461&partnerID=8YFLogxK

U2 - 10.4161/21624011.2014.963413

DO - 10.4161/21624011.2014.963413

M3 - Article

C2 - 25914862

AN - SCOPUS:84938631461

VL - 3

SP - e963413-1-e963413-3

JO - OncoImmunology

JF - OncoImmunology

SN - 2162-4011

IS - 11

ER -