Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade

Janis M Taube

doi:10.4161/21624011.2014.963413

Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade

Janis M Taube

School of Medicine

Research output: Contribution to journal › Article

Abstract

Focal tumor cell PD-L1 expression adjacent to TIL can be used as a surrogate marker of an ongoing antitumor host response, which may be unleashed by PD-1 blockade. Tumor cell PD-L1 expression is superior to TIL PD-1 expression and the presence of TIL alone, when predicting response to anti-PD-1 therapy.

Original language	English (US)
Pages (from-to)	e963413-1-e963413-3
Journal	OncoImmunology
Volume	3
Issue number	11
DOIs	https://doi.org/10.4161/21624011.2014.963413
State	Published - Nov 2 2014

Fingerprint

Tumor Microenvironment

Immune System

Neoplasms

Biomarkers

Therapeutics

Keywords

cancer immunotherapy
PD-1
PD-L1
PD-L2
tumor microenvironment

ASJC Scopus subject areas

Immunology and Allergy
Oncology
Immunology

Cite this

Taube, J. M. (2014). Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade. OncoImmunology, 3(11), e963413-1-e963413-3. https://doi.org/10.4161/21624011.2014.963413

Unleashing the immune system : PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade. / Taube, Janis M.

In: OncoImmunology, Vol. 3, No. 11, 02.11.2014, p. e963413-1-e963413-3.

Research output: Contribution to journal › Article

Taube, JM 2014, 'Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade', OncoImmunology, vol. 3, no. 11, pp. e963413-1-e963413-3. https://doi.org/10.4161/21624011.2014.963413

Taube JM. Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade. OncoImmunology. 2014 Nov 2;3(11):e963413-1-e963413-3. https://doi.org/10.4161/21624011.2014.963413

Taube, Janis M. / Unleashing the immune system : PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade. In: OncoImmunology. 2014 ; Vol. 3, No. 11. pp. e963413-1-e963413-3.

@article{7f09385bb0a044d3b859b105d7902128,

title = "Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade",

abstract = "Focal tumor cell PD-L1 expression adjacent to TIL can be used as a surrogate marker of an ongoing antitumor host response, which may be unleashed by PD-1 blockade. Tumor cell PD-L1 expression is superior to TIL PD-1 expression and the presence of TIL alone, when predicting response to anti-PD-1 therapy.",

keywords = "cancer immunotherapy, PD-1, PD-L1, PD-L2, tumor microenvironment",

author = "Taube, {Janis M}",

year = "2014",

month = "11",

day = "2",

doi = "10.4161/21624011.2014.963413",

language = "English (US)",

volume = "3",

pages = "e963413--1--e963413--3",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Landes Bioscience",

number = "11",

}

TY - JOUR

T1 - Unleashing the immune system

T2 - PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade

AU - Taube, Janis M

PY - 2014/11/2

Y1 - 2014/11/2

N2 - Focal tumor cell PD-L1 expression adjacent to TIL can be used as a surrogate marker of an ongoing antitumor host response, which may be unleashed by PD-1 blockade. Tumor cell PD-L1 expression is superior to TIL PD-1 expression and the presence of TIL alone, when predicting response to anti-PD-1 therapy.

AB - Focal tumor cell PD-L1 expression adjacent to TIL can be used as a surrogate marker of an ongoing antitumor host response, which may be unleashed by PD-1 blockade. Tumor cell PD-L1 expression is superior to TIL PD-1 expression and the presence of TIL alone, when predicting response to anti-PD-1 therapy.

KW - cancer immunotherapy

KW - PD-1

KW - PD-L1

KW - PD-L2

KW - tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=84938631461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938631461&partnerID=8YFLogxK

U2 - 10.4161/21624011.2014.963413

DO - 10.4161/21624011.2014.963413

M3 - Article

C2 - 25914862

AN - SCOPUS:84938631461

VL - 3

SP - e963413-1-e963413-3

JO - OncoImmunology

JF - OncoImmunology

SN - 2162-4011

IS - 11

ER -

Access to Document

10.4161/21624011.2014.963413