Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade

Janis M. Taube

doi:10.4161/21624011.2014.963413

Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade

Janis M. Taube

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Focal tumor cell PD-L1 expression adjacent to TIL can be used as a surrogate marker of an ongoing antitumor host response, which may be unleashed by PD-1 blockade. Tumor cell PD-L1 expression is superior to TIL PD-1 expression and the presence of TIL alone, when predicting response to anti-PD-1 therapy.

Original language	English (US)
Pages (from-to)	e963413-1-e963413-3
Journal	OncoImmunology
Volume	3
Issue number	11
DOIs	https://doi.org/10.4161/21624011.2014.963413
State	Published - Nov 2 2014

Keywords

PD-1
PD-L1
PD-L2
cancer immunotherapy
tumor microenvironment

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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