Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade

Research output: Contribution to journalArticlepeer-review

Abstract

Focal tumor cell PD-L1 expression adjacent to TIL can be used as a surrogate marker of an ongoing antitumor host response, which may be unleashed by PD-1 blockade. Tumor cell PD-L1 expression is superior to TIL PD-1 expression and the presence of TIL alone, when predicting response to anti-PD-1 therapy.

Original languageEnglish (US)
Pages (from-to)e963413-1-e963413-3
JournalOncoImmunology
Volume3
Issue number11
DOIs
StatePublished - Nov 2 2014

Keywords

  • PD-1
  • PD-L1
  • PD-L2
  • cancer immunotherapy
  • tumor microenvironment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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