Unkind cytokines: Current evidence for the potential role of cytokines in immune-mediated depression

Research output: Contribution to journalReview article


A great deal of interest has recently become focused on interactions between the nervous and the immune systems, including the potential for alterations in immune function to contribute to various psychiatric and neurologic disorders. Evidence suggests that cytokines may be involved in the development of depression. Immune-mediated mechanisms in the pathophysiology of some types of depression are reviewed from both clinical and animal studies and the difficulties inherent in studying the interplay of these two complex systems in the development of depression are described.

Original languageEnglish (US)
Pages (from-to)477-483
Number of pages7
JournalInternational Review of Psychiatry
Issue number6
StatePublished - Dec 1 2005


ASJC Scopus subject areas

  • Psychiatry and Mental health

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