University of Wisconsin solution for human donor heart preservation: Initial clinical experience

Valluvan Jeevanandam, Mark L. Barr, Joseph S. Auteri, Juan A. Sanchez, Gary Y. Ott, Felicia A. Schenkel, Charles Marboe, Craig R. Smith, Eric A. Rose

Research output: Contribution to journalArticle

Abstract

Although in vitro and primate orthotopic transplant experiments have suggested the superiority of University of Wisconsin solution (UWS) compared with crystalloid cardioplegia and saline solution storage for hypothermic heart preservation, concerns about the viscosity and the high potassium concentration of UWS have precluded its use in human cardiac transplantation. To test the safety and efficacy of UWS, 16 patients received hearts arrested with, flushed with, and stored in UWS at 4 °C for a mean ischemic time of 153.3 ± 30.7 minutes. After reperfusion, the hearts contracted vigorously and attained a stable sinus rhythm within 4.0 ± 2.4 minutes, and the patients were weaned from bypass in 24.5 ± 8.0 minutes. There was no evidence of acute or chronic ischemic myocardial injury by enzymatic analysis, electrocardiography, or biopsy specimen histology. The results suggest UWS can be safely used, within currently accepted limits of donor ischemic time, to arrest and preserve human hearts for transplantation. Further studies of preservation are required to compare UWS with crystalloid cardioplegia and saline solution storage and to test the ability of UWS to prolong the period of safe donor hypothermic ischemia in clinical heart transplantation.

Original languageEnglish (US)
Pages (from-to)1213-1216
Number of pages4
JournalThe Annals of thoracic surgery
Volume52
Issue number6
DOIs
StatePublished - Dec 1991

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ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Jeevanandam, V., Barr, M. L., Auteri, J. S., Sanchez, J. A., Ott, G. Y., Schenkel, F. A., Marboe, C., Smith, C. R., & Rose, E. A. (1991). University of Wisconsin solution for human donor heart preservation: Initial clinical experience. The Annals of thoracic surgery, 52(6), 1213-1216. https://doi.org/10.1016/0003-4975(91)90003-9