TY - JOUR
T1 - Univariate genetic analysis of blood pressure in children (The Medical College of Virginia Twin Study)
AU - Schieken, Richard M.
AU - Eaves, Lindon J.
AU - Hewitt, John K.
AU - Mosteller, Michael
AU - Bodurtha, Joann N.
AU - Moskowitz, William B.
AU - Nance, Walter E.
N1 - Funding Information:
From the Children’s Medical Center, Division of Pediatric Cardiology, and the Department of Human Genetics, The Medical College of Virginia, Richmond, Virginia. This study was supported by grant ROl HL31010 from the National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, Maryland. Manuscript received May $1989; revised manuscript received August 18,1989, and accepted August 19.
PY - 1989/12/1
Y1 - 1989/12/1
N2 - The relative contributions of genetic, individual environmental and shared environmental effects on resting blood pressure (BP) and heart rate (HR) were studied in prepubescent twins. The study population consisted of 251 caucasian 11-year-old twin pairs. Correlations were higher for all variables in monozygotic twins compared to dizygotic twins; this is consistent with a significant genetic effect. Path analysis revealed that the model of additive genetic and individual environmental effects fit systolic BP, diastolic BP and HR. In boys and girls, sex-specific genetic effects controlled systolic BP. The magnitudes of the sex-specific genetic effects on systolic BP were similar in both boys and girls and accounted for 66% of the variance. In boys, for diastolic BP, genetic effects accounted for 64% of the variance while in girls they accounted for 51%. These results provide no evidence for different genetic effects on HR in boys or girls. No shared environmental effects were detected. The large sample size and design, using different-sex dizygotic twins of the same age, establish that genes play an important role in the influence of resting BP and HR and that there are sex-specific genetic contributions in early pubertal children.
AB - The relative contributions of genetic, individual environmental and shared environmental effects on resting blood pressure (BP) and heart rate (HR) were studied in prepubescent twins. The study population consisted of 251 caucasian 11-year-old twin pairs. Correlations were higher for all variables in monozygotic twins compared to dizygotic twins; this is consistent with a significant genetic effect. Path analysis revealed that the model of additive genetic and individual environmental effects fit systolic BP, diastolic BP and HR. In boys and girls, sex-specific genetic effects controlled systolic BP. The magnitudes of the sex-specific genetic effects on systolic BP were similar in both boys and girls and accounted for 66% of the variance. In boys, for diastolic BP, genetic effects accounted for 64% of the variance while in girls they accounted for 51%. These results provide no evidence for different genetic effects on HR in boys or girls. No shared environmental effects were detected. The large sample size and design, using different-sex dizygotic twins of the same age, establish that genes play an important role in the influence of resting BP and HR and that there are sex-specific genetic contributions in early pubertal children.
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U2 - 10.1016/0002-9149(89)90577-8
DO - 10.1016/0002-9149(89)90577-8
M3 - Article
C2 - 2686389
AN - SCOPUS:0024396026
SN - 0002-9149
VL - 64
SP - 1333
EP - 1337
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 19
ER -