Abstract
In assessing the present status of rodent models for the analysis and prevention of carcinogenesis, the discussion emphasized that models exist for very few of the major cancers occurring in the United States and Japan. Almost without exception, those that do exist were invented for etiological and mechanistic studies of chemical and physical carcinogenesis. Applicability to cancer chemoprevention was not a primary objective in their development. However, they have been adapted and used for identifying and characterizing chemopreventive agents out of necessity. It is therefore not surprising that they generally fail to fulfill most or all of the requisites of 'ideal' models enumerated above, and consequently, the validity of data produced through their use has been questioned. Evolution of future mechanistic models may similarly lead to their eventual adaptation to chemoprevention, but advances will be fragmentary, and the rate of progress seems likely to be slow. Animal models discussed at this workshop were designed specifically for this purpose and promise to expedite the accumulation of valuable new information. Nonetheless, recurrent discussion identified the urgent need for institution of a major, dedicated research initiative with the expressed objective of developing rodent models for organ-specific chemoprevention based on current understanding of underlying genetic and cellular processes. No concerted programs with this objective presently exist either in the United States or Japan. In addition to research specifically designed to meet this need, efforts should be made to involve investigators developing mechanistic animal models in the validation of their models through modulating cancer development by chemopreventive agents. Support for such research initiatives will be essential to continued progress toward the overall objective of identifying safe and effective cancer chemopreventive agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1033-1037 |
| Number of pages | 5 |
| Journal | Cancer Epidemiology Biomarkers and Prevention |
| Volume | 8 |
| Issue number | 11 |
| State | Published - 1999 |
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ASJC Scopus subject areas
- Epidemiology
- Oncology
Cite this
United States-Japan workshop on new rodent models for the analysis and prevention of carcinogenesis. / Kensler, Thomas W; Tsuda, H.; Wogan, G. N.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 8, No. 11, 1999, p. 1033-1037.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - United States-Japan workshop on new rodent models for the analysis and prevention of carcinogenesis
AU - Kensler, Thomas W
AU - Tsuda, H.
AU - Wogan, G. N.
PY - 1999
Y1 - 1999
N2 - In assessing the present status of rodent models for the analysis and prevention of carcinogenesis, the discussion emphasized that models exist for very few of the major cancers occurring in the United States and Japan. Almost without exception, those that do exist were invented for etiological and mechanistic studies of chemical and physical carcinogenesis. Applicability to cancer chemoprevention was not a primary objective in their development. However, they have been adapted and used for identifying and characterizing chemopreventive agents out of necessity. It is therefore not surprising that they generally fail to fulfill most or all of the requisites of 'ideal' models enumerated above, and consequently, the validity of data produced through their use has been questioned. Evolution of future mechanistic models may similarly lead to their eventual adaptation to chemoprevention, but advances will be fragmentary, and the rate of progress seems likely to be slow. Animal models discussed at this workshop were designed specifically for this purpose and promise to expedite the accumulation of valuable new information. Nonetheless, recurrent discussion identified the urgent need for institution of a major, dedicated research initiative with the expressed objective of developing rodent models for organ-specific chemoprevention based on current understanding of underlying genetic and cellular processes. No concerted programs with this objective presently exist either in the United States or Japan. In addition to research specifically designed to meet this need, efforts should be made to involve investigators developing mechanistic animal models in the validation of their models through modulating cancer development by chemopreventive agents. Support for such research initiatives will be essential to continued progress toward the overall objective of identifying safe and effective cancer chemopreventive agents.
AB - In assessing the present status of rodent models for the analysis and prevention of carcinogenesis, the discussion emphasized that models exist for very few of the major cancers occurring in the United States and Japan. Almost without exception, those that do exist were invented for etiological and mechanistic studies of chemical and physical carcinogenesis. Applicability to cancer chemoprevention was not a primary objective in their development. However, they have been adapted and used for identifying and characterizing chemopreventive agents out of necessity. It is therefore not surprising that they generally fail to fulfill most or all of the requisites of 'ideal' models enumerated above, and consequently, the validity of data produced through their use has been questioned. Evolution of future mechanistic models may similarly lead to their eventual adaptation to chemoprevention, but advances will be fragmentary, and the rate of progress seems likely to be slow. Animal models discussed at this workshop were designed specifically for this purpose and promise to expedite the accumulation of valuable new information. Nonetheless, recurrent discussion identified the urgent need for institution of a major, dedicated research initiative with the expressed objective of developing rodent models for organ-specific chemoprevention based on current understanding of underlying genetic and cellular processes. No concerted programs with this objective presently exist either in the United States or Japan. In addition to research specifically designed to meet this need, efforts should be made to involve investigators developing mechanistic animal models in the validation of their models through modulating cancer development by chemopreventive agents. Support for such research initiatives will be essential to continued progress toward the overall objective of identifying safe and effective cancer chemopreventive agents.
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UR - http://www.scopus.com/inward/citedby.url?scp=0032724242&partnerID=8YFLogxK
M3 - Article
C2 - 10566560
AN - SCOPUS:0032724242
VL - 8
SP - 1033
EP - 1037
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 11
ER -