Unique patterns of diffusion directionality in rat brain tumors revealed by high-resolution diffusion tensor MRI

Jiangyang Zhang, Peter C.M. Van Zijl, John Laterra, Amandeep Salhotra, Bachchu Lal, Susumu Mori, Jinyuan Zhou

Research output: Contribution to journalArticlepeer-review

Abstract

Diffusion tensor imaging (DTI) is a new technique that uses the microscopic motion of water molecules to probe tissue 3D microstructures. In this study, high-resolution DTI was performed on rats bearing intracranial 9L gliosarcoma, F98 glioma, and human glioblastoma. It was found that the tumors consisted of central zones with low diffusion anisotropy and peripheral structures (rim) with high diffusion anisotropy. In the rims, water diffusion directionality formed a circular pattern for the 9L and F98 tumors, and a radial pattern for the human glioblastoma xenografts. These well-organized diffusion patterns appeared at an sarly stage postimplantation and continued to exist with tumor growth in all three models. High-resolution ex vivo imaging and histology confirmed the in vivo findings. These distinct patterns, undetectable with conventional MRI, may reflect tumor organization and growth patterns at the cellular level.

Original languageEnglish (US)
Pages (from-to)454-462
Number of pages9
JournalMagnetic resonance in medicine
Volume58
Issue number3
DOIs
StatePublished - Sep 2007

Keywords

  • DTI
  • Diffusion pattern
  • Diffusion tensor imaging
  • Glioma
  • Growth pattern
  • High resolution
  • Microstructure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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