Unique aspects of clinical trials of invasive therapies for chronic pain

Steven Cohen, Mark Wallace, Richard L. Rauck, Brett R. Stacey

Research output: Contribution to journalArticle

Abstract

Nearly all who review the literature conclude that the role of invasive procedures to treat chronic pain is poorly characterized because of the lack of "definitive" studies. The overt nature of invasive treatments, along with the risks, technical skills, and costs involved create challenges to study them. However, these challenges do not completely preclude evaluating invasive procedure effectiveness and safety using well-designed methods. This article reviews the challenges of studying outcomes of invasive therapies to treat pain and discuss possible solutions. Although the following discussion can apply to most invasive therapies to treat chronic pain, it is beyond the scope of the article to individually cover every invasive therapy used. Therefore, most of the examples focus on injection therapies to treat spine pain, spinal cord stimulation, and intrathecal drug therapies.

Original languageEnglish (US)
Article numbere687
JournalPain Reports
Volume4
Issue number3
DOIs
StatePublished - May 1 2019

Fingerprint

Chronic Pain
Clinical Trials
Spinal Cord Stimulation
Therapeutics
Pain
Spine
Safety
Costs and Cost Analysis
Drug Therapy
Injections

Keywords

  • Chronic pain
  • Clinical trial
  • Design
  • Invasive
  • Procedures

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Unique aspects of clinical trials of invasive therapies for chronic pain. / Cohen, Steven; Wallace, Mark; Rauck, Richard L.; Stacey, Brett R.

In: Pain Reports, Vol. 4, No. 3, e687, 01.05.2019.

Research output: Contribution to journalArticle

Cohen, Steven ; Wallace, Mark ; Rauck, Richard L. ; Stacey, Brett R. / Unique aspects of clinical trials of invasive therapies for chronic pain. In: Pain Reports. 2019 ; Vol. 4, No. 3.
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