Unique Abnormalities in Right Ventricular Longitudinal Strain in Systemic Sclerosis Patients

Monica Mukherjee, Shang En Chung, Von Khue Ton, Ryan J. Tedford, Laura Hummers, Fredrick Wigley, Theodore P. Abraham, Ami Shah

Research output: Contribution to journalArticle

Abstract

Background - Cardiac involvement in systemic sclerosis (scleroderma [SSc]) adversely affects long-term prognosis, often remaining undetectable despite close clinical examination and 2-dimensional echocardiographic monitoring. Speckle-derived strain of the right ventricle (RV) was utilized to detect occult abnormalities in regional and global contractility in SSc patients. Methods and Results - A total of 138 SSc patients with technically adequate echocardiograms was studied and compared with 40 age- and sex-matched healthy non-SSc controls. Standard assessment of RV chamber function included tricuspid annular plane systolic excursion and fractional area change. RV longitudinal systolic speckle-derived strain was assessed in the basal, mid, and apical free wall. Tricuspid annular plane systolic excursion was not different between groups (P=0.307). Although fractional area change was lower in SSc patients than in controls (mean, 48.9 versus 55; P=0.002), the mean fractional area change was still within the normal range (>35). In contrast, RV longitudinal systolic speckle-derived strain measures were significantly different between groups, both globally (-20.4% versus -17.7%; P=0.005) and regionally: they were decreased in the apex (-8.5% versus -17.1%; P

Original languageEnglish (US)
Article numbere003792
JournalCirculation: Cardiovascular Imaging
Volume9
Issue number6
DOIs
StatePublished - Jun 1 2016

Fingerprint

Systemic Scleroderma
Heart Ventricles
Sclerosis
Reference Values

Keywords

  • cardiomyopathies
  • heart ventricles
  • hypertension, pulmonary
  • scleroderma, systemic
  • ventricular function, right

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Unique Abnormalities in Right Ventricular Longitudinal Strain in Systemic Sclerosis Patients. / Mukherjee, Monica; Chung, Shang En; Ton, Von Khue; Tedford, Ryan J.; Hummers, Laura; Wigley, Fredrick; Abraham, Theodore P.; Shah, Ami.

In: Circulation: Cardiovascular Imaging, Vol. 9, No. 6, e003792, 01.06.2016.

Research output: Contribution to journalArticle

@article{148812bfe4ae46a799b481a60d9186dd,
title = "Unique Abnormalities in Right Ventricular Longitudinal Strain in Systemic Sclerosis Patients",
abstract = "Background - Cardiac involvement in systemic sclerosis (scleroderma [SSc]) adversely affects long-term prognosis, often remaining undetectable despite close clinical examination and 2-dimensional echocardiographic monitoring. Speckle-derived strain of the right ventricle (RV) was utilized to detect occult abnormalities in regional and global contractility in SSc patients. Methods and Results - A total of 138 SSc patients with technically adequate echocardiograms was studied and compared with 40 age- and sex-matched healthy non-SSc controls. Standard assessment of RV chamber function included tricuspid annular plane systolic excursion and fractional area change. RV longitudinal systolic speckle-derived strain was assessed in the basal, mid, and apical free wall. Tricuspid annular plane systolic excursion was not different between groups (P=0.307). Although fractional area change was lower in SSc patients than in controls (mean, 48.9 versus 55; P=0.002), the mean fractional area change was still within the normal range (>35). In contrast, RV longitudinal systolic speckle-derived strain measures were significantly different between groups, both globally (-20.4{\%} versus -17.7{\%}; P=0.005) and regionally: they were decreased in the apex (-8.5{\%} versus -17.1{\%}; P",
keywords = "cardiomyopathies, heart ventricles, hypertension, pulmonary, scleroderma, systemic, ventricular function, right",
author = "Monica Mukherjee and Chung, {Shang En} and Ton, {Von Khue} and Tedford, {Ryan J.} and Laura Hummers and Fredrick Wigley and Abraham, {Theodore P.} and Ami Shah",
year = "2016",
month = "6",
day = "1",
doi = "10.1161/CIRCIMAGING.115.003792",
language = "English (US)",
volume = "9",
journal = "Circulation: Cardiovascular Imaging",
issn = "1941-9651",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Unique Abnormalities in Right Ventricular Longitudinal Strain in Systemic Sclerosis Patients

AU - Mukherjee, Monica

AU - Chung, Shang En

AU - Ton, Von Khue

AU - Tedford, Ryan J.

AU - Hummers, Laura

AU - Wigley, Fredrick

AU - Abraham, Theodore P.

AU - Shah, Ami

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Background - Cardiac involvement in systemic sclerosis (scleroderma [SSc]) adversely affects long-term prognosis, often remaining undetectable despite close clinical examination and 2-dimensional echocardiographic monitoring. Speckle-derived strain of the right ventricle (RV) was utilized to detect occult abnormalities in regional and global contractility in SSc patients. Methods and Results - A total of 138 SSc patients with technically adequate echocardiograms was studied and compared with 40 age- and sex-matched healthy non-SSc controls. Standard assessment of RV chamber function included tricuspid annular plane systolic excursion and fractional area change. RV longitudinal systolic speckle-derived strain was assessed in the basal, mid, and apical free wall. Tricuspid annular plane systolic excursion was not different between groups (P=0.307). Although fractional area change was lower in SSc patients than in controls (mean, 48.9 versus 55; P=0.002), the mean fractional area change was still within the normal range (>35). In contrast, RV longitudinal systolic speckle-derived strain measures were significantly different between groups, both globally (-20.4% versus -17.7%; P=0.005) and regionally: they were decreased in the apex (-8.5% versus -17.1%; P

AB - Background - Cardiac involvement in systemic sclerosis (scleroderma [SSc]) adversely affects long-term prognosis, often remaining undetectable despite close clinical examination and 2-dimensional echocardiographic monitoring. Speckle-derived strain of the right ventricle (RV) was utilized to detect occult abnormalities in regional and global contractility in SSc patients. Methods and Results - A total of 138 SSc patients with technically adequate echocardiograms was studied and compared with 40 age- and sex-matched healthy non-SSc controls. Standard assessment of RV chamber function included tricuspid annular plane systolic excursion and fractional area change. RV longitudinal systolic speckle-derived strain was assessed in the basal, mid, and apical free wall. Tricuspid annular plane systolic excursion was not different between groups (P=0.307). Although fractional area change was lower in SSc patients than in controls (mean, 48.9 versus 55; P=0.002), the mean fractional area change was still within the normal range (>35). In contrast, RV longitudinal systolic speckle-derived strain measures were significantly different between groups, both globally (-20.4% versus -17.7%; P=0.005) and regionally: they were decreased in the apex (-8.5% versus -17.1%; P

KW - cardiomyopathies

KW - heart ventricles

KW - hypertension, pulmonary

KW - scleroderma, systemic

KW - ventricular function, right

UR - http://www.scopus.com/inward/record.url?scp=84975852995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975852995&partnerID=8YFLogxK

U2 - 10.1161/CIRCIMAGING.115.003792

DO - 10.1161/CIRCIMAGING.115.003792

M3 - Article

C2 - 27266598

AN - SCOPUS:84975852995

VL - 9

JO - Circulation: Cardiovascular Imaging

JF - Circulation: Cardiovascular Imaging

SN - 1941-9651

IS - 6

M1 - e003792

ER -