TY - JOUR
T1 - Unintentional weight loss predicts decline in activities of daily living function and life-space mobility over 4 years among community-dwelling older adults
AU - Ritchie, Christine S.
AU - Locher, Julie L.
AU - Roth, David L.
AU - McVie, Theresa
AU - Sawyer, Patricia
AU - Allman, Richard
N1 - Funding Information:
ACKNOWLEDGMENTS This work was supported by the National Institute on Aging (R29 AG13885, Alessi), VA Health Services Research & Development (IIR 01-053-1, Alessi; AIA 03-047, Martin), the UCLA Claude Pepper Older Americans Independence Center (AG-10415, Career Development Award, Martin), and the VA Greater Los Angeles Healthcare System Geriatric Research, Education and Clinical Center.
PY - 2008/1
Y1 - 2008/1
N2 - Background. The relationship between body mass index (BMI), weight loss, and changes in activities of daily living (ADL) function and mobility in older adults is not clear. We sought to study the relationship between BMI and weight loss on the rate of decline in ADL function and life-space mobility over a 4-year period among older African Americans and whites. Methods. The participants were 983 enrollees in the University of Alabama at Birmingham (UAB) Study of Aging, a longitudinal study of mobility among community-dwelling older adults stratified to achieve a balanced sample in terms of sex, race, and residence. Primary outcome measures were changes in ADL function and mobility assessed by the UAB Study of Aging Life-Space Assessment (LSA) which were measured every 6 months. Results. Relative to normal weight participants, those with BMI levels in the obese range did not show more rapid ADL functional decline, but a history of unintentional weight loss predicted more rapid decline. Relative to normal-weight participants, other BMI categories were not associated with more rapid decline in LSA scores. However, unintentional weight loss predicted more rapid declines in LSA. Intentional weight loss had no relation to ADL function or LSA decline. Conclusions. In this population of community-dwelling older African Americans and whites, neither BMI nor intentional weight loss had an association with rate of functional decline. Unintentional weight loss had a negative relation with rate of functional decline, regardless of baseline BMI. Whether this is causal remains to be determined.
AB - Background. The relationship between body mass index (BMI), weight loss, and changes in activities of daily living (ADL) function and mobility in older adults is not clear. We sought to study the relationship between BMI and weight loss on the rate of decline in ADL function and life-space mobility over a 4-year period among older African Americans and whites. Methods. The participants were 983 enrollees in the University of Alabama at Birmingham (UAB) Study of Aging, a longitudinal study of mobility among community-dwelling older adults stratified to achieve a balanced sample in terms of sex, race, and residence. Primary outcome measures were changes in ADL function and mobility assessed by the UAB Study of Aging Life-Space Assessment (LSA) which were measured every 6 months. Results. Relative to normal weight participants, those with BMI levels in the obese range did not show more rapid ADL functional decline, but a history of unintentional weight loss predicted more rapid decline. Relative to normal-weight participants, other BMI categories were not associated with more rapid decline in LSA scores. However, unintentional weight loss predicted more rapid declines in LSA. Intentional weight loss had no relation to ADL function or LSA decline. Conclusions. In this population of community-dwelling older African Americans and whites, neither BMI nor intentional weight loss had an association with rate of functional decline. Unintentional weight loss had a negative relation with rate of functional decline, regardless of baseline BMI. Whether this is causal remains to be determined.
KW - Body composition
KW - Function
KW - Mobility
KW - Weight loss
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U2 - 10.1093/gerona/63.1.67
DO - 10.1093/gerona/63.1.67
M3 - Article
C2 - 18245763
AN - SCOPUS:41149166760
SN - 1079-5006
VL - 63
SP - 67
EP - 75
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 1
ER -