Unimpaired maintenance of a conditioned avoidance response in the rat with diabetes insipidus

John F. Celestian, Robert J. Carey, Myron Miller

Research output: Contribution to journalArticlepeer-review

Abstract

The ability to maintain a conditioned avoidance response (CAR) was studied in normal Long-Evans rats and rats of the Brattleboro strain which were either homozygous or heterozygous for hereditary hypothalamic diabetes insipidus (DI). Homozygous DI rats had a lower CAR acquisition rate than did normal or heterozygous DI rats. However, the homozygous DI rats exhibited significantly greater CAR retention than did the other animals over the total period of extinction testing. The greater CAR retention could not be accounted for by either increased sensitivity to the electric foot shock used as the unconditioned stimulus or by perching on the metal center barrier of the training shuttle box, a form of behavior unique to the homozygous DI rats. Since the homozygous DI rat is totally lacking in hypothalamic antidiuretic hormone (ADH), the greater CAR retention of these animals indicates that ADH is not a requirement for CAR retention.

Original languageEnglish (US)
Pages (from-to)707-711
Number of pages5
JournalPhysiology and Behavior
Volume15
Issue number6
DOIs
StatePublished - Dec 1975
Externally publishedYes

Keywords

  • Conditioned avoidance response (CAR)
  • Diabetes insipidus
  • Extinction
  • Retention
  • Vasopressin (ADH)

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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