Unilateral olfactory sensitivity in multiple sclerosis

Kimberley P. Good, Isabelle A. Tourbier, Paul Moberg, Jennifer L. Cuzzocreo, Rena J. Geckle, David Mark Yousem, Dzung L. Pham, Richard L. Doty

Research output: Contribution to journalArticle

Abstract

It is not known whether lateralized olfactory sensitivity deficits are present in MS. Since projections from the olfactory bulb to the olfactory cortex are largely ipsilateral, and since both functional imaging and psychophysical studies suggest that the right side of the brain may be more involved in olfactory processing than the left, we addressed this issue by administering well-validated tests of odor detection, along with tests of odor identification, to each side of the nose of 73 MS patients and 73 age-, gender-, and race-matched normal controls. We also determined, in 63 of the MS patients, whether correlations were present between the olfactory test measures and MRI-determined lesions in brain regions ipsilateral and contralateral to the nose side that was tested. No significant left:right differences in either olfactory sensitivity or identification were present, although in both cases mean performance was lower in the MS than in the control subjects (ps < 0.0001). Scores on the two sides of the nose were positively correlated with one another (threshold r = 0.56, p < 0.0001; Identification r = 0.71, p < 0.0001). The percent of MS patients whose bilateral test scores fell below the 10th percentile of controls did not differ between the odor identification and detection threshold tests. Both left and right odor identification and detection test scores were weakly correlated with lesion volumes in temporal and frontal lobe brain regions (r's < 0.40). Our findings demonstrate that MS does not differentially influence odor perception on left and right sides of the nose, regardless of whether sensitivity or identification is being measured. They also indicate that tests of odor identification and detection are similarly influenced by MS and that such influences are associated with central brain lesions.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalPhysiology and Behavior
Volume168
DOIs
StatePublished - Jan 1 2017

Fingerprint

Multiple Sclerosis
Nose
Brain
Olfactory Bulb
Frontal Lobe
Temporal Lobe
Identification (Psychology)
Odorants

Keywords

  • Brain laterality
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Olfaction
  • Sex differences
  • Threshold
  • UPSIT

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Philosophy
  • Behavioral Neuroscience

Cite this

Good, K. P., Tourbier, I. A., Moberg, P., Cuzzocreo, J. L., Geckle, R. J., Yousem, D. M., ... Doty, R. L. (2017). Unilateral olfactory sensitivity in multiple sclerosis. Physiology and Behavior, 168, 24-30. https://doi.org/10.1016/j.physbeh.2016.10.017

Unilateral olfactory sensitivity in multiple sclerosis. / Good, Kimberley P.; Tourbier, Isabelle A.; Moberg, Paul; Cuzzocreo, Jennifer L.; Geckle, Rena J.; Yousem, David Mark; Pham, Dzung L.; Doty, Richard L.

In: Physiology and Behavior, Vol. 168, 01.01.2017, p. 24-30.

Research output: Contribution to journalArticle

Good, KP, Tourbier, IA, Moberg, P, Cuzzocreo, JL, Geckle, RJ, Yousem, DM, Pham, DL & Doty, RL 2017, 'Unilateral olfactory sensitivity in multiple sclerosis', Physiology and Behavior, vol. 168, pp. 24-30. https://doi.org/10.1016/j.physbeh.2016.10.017
Good KP, Tourbier IA, Moberg P, Cuzzocreo JL, Geckle RJ, Yousem DM et al. Unilateral olfactory sensitivity in multiple sclerosis. Physiology and Behavior. 2017 Jan 1;168:24-30. https://doi.org/10.1016/j.physbeh.2016.10.017
Good, Kimberley P. ; Tourbier, Isabelle A. ; Moberg, Paul ; Cuzzocreo, Jennifer L. ; Geckle, Rena J. ; Yousem, David Mark ; Pham, Dzung L. ; Doty, Richard L. / Unilateral olfactory sensitivity in multiple sclerosis. In: Physiology and Behavior. 2017 ; Vol. 168. pp. 24-30.
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