Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia

Anne Louise Oaklander, Allan J. Belzberg

Research output: Contribution to journalArticlepeer-review

Abstract

Injury makes sensory neurons abnormally excitable and triggers coincident alterations in relative levels of different types of voltage-gated sodium channels that they express. We report that nerve injury depress levels of SCN10A-specific mRNA in contralateral as well as ipsilateral dorsal root ganglia of rats, suggesting a possible peripheral mechanism for the contralateral 'mirror-image' hyperalgesia described in nerve-injured humans and experimental animals.

Original languageEnglish (US)
Pages (from-to)162-165
Number of pages4
JournalMolecular Brain Research
Volume52
Issue number1
DOIs
StatePublished - Dec 1 1997

Keywords

  • Dorsal root ganglion
  • Hyperalgesia
  • Nerve injury
  • Neuropathic pain
  • RT-PCR
  • SCN10A
  • Voltage-gated sodium channel
  • α-SNS

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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