TY - JOUR
T1 - Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism
AU - Senthilkumar, Karuppagounder S.
AU - Saravanan, Karuppagounder S.
AU - Chandra, Goutam
AU - Sindhu, Kizhakke M.
AU - Jayakrishnan, A.
AU - Mohanakumar, Kochupurackal P.
N1 - Funding Information:
K.S. Senthilkumar received post-graduate fellowship from the University Grants Commission. K.S. Saravanan, K.M. Sindhu and G. Chandra are senior research fellows of the Council of Scientific & Industrial Research.
PY - 2007/11/22
Y1 - 2007/11/22
N2 - Dopaminergic functional recovery following controlled release of dopamine from biodegradable polymer matrices implanted in the lesioned striatum was investigated in a hemiparkinsonian animal model. Significant dopamine depletion in the striatum ipsilateral to the side of infusion was observed in animals unilaterally infused with 6-hydroxydopamine (6-OHDA) in the substatia nigra. These animals displayed apomorphine-induced contralateral rotational behavior, when examined on the 16th day. Implantation of a controlled release delivery system (hydrogel obtained by mixing dextran dialdehyde cross-linked with gelatin) containing dopamine in the denervated striatum on the 1st day or the 18th day significantly abolished the apomorphine-induced contralateral rotational behavior in these animals. The recovery was visible for about 17 days, thereafter the behavioral bias reappeared. The present results indicate that dopamine released from the polymer matrices alleviates behavioral bias in experimental parkinsonism, implying use of such technologies as an alternative method for the treatment of Parkinson's disease. This approach is useful in reducing the oral dose of drugs that are with severe systemic effects, and that develop tolerance.
AB - Dopaminergic functional recovery following controlled release of dopamine from biodegradable polymer matrices implanted in the lesioned striatum was investigated in a hemiparkinsonian animal model. Significant dopamine depletion in the striatum ipsilateral to the side of infusion was observed in animals unilaterally infused with 6-hydroxydopamine (6-OHDA) in the substatia nigra. These animals displayed apomorphine-induced contralateral rotational behavior, when examined on the 16th day. Implantation of a controlled release delivery system (hydrogel obtained by mixing dextran dialdehyde cross-linked with gelatin) containing dopamine in the denervated striatum on the 1st day or the 18th day significantly abolished the apomorphine-induced contralateral rotational behavior in these animals. The recovery was visible for about 17 days, thereafter the behavioral bias reappeared. The present results indicate that dopamine released from the polymer matrices alleviates behavioral bias in experimental parkinsonism, implying use of such technologies as an alternative method for the treatment of Parkinson's disease. This approach is useful in reducing the oral dose of drugs that are with severe systemic effects, and that develop tolerance.
KW - 6-Hydroxydopamine
KW - Apomorphine
KW - Controlled release
KW - Dextran dialdehyde cross-linked gelatin hydrogel
KW - Dopamine
KW - Parkinson's disease
KW - Rotational behavior
KW - Striatal implantation
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UR - http://www.scopus.com/inward/citedby.url?scp=34548668709&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2007.06.025
DO - 10.1016/j.bbr.2007.06.025
M3 - Article
C2 - 17765334
AN - SCOPUS:34548668709
SN - 0166-4328
VL - 184
SP - 11
EP - 18
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -