Unilateral humoral rejection after reoperative single-lung transplant

Claude A. Beaty, Alexander Yang, Timothy J. George, Peter B Illei, Ashish S. Shah

Research output: Contribution to journalArticle

Abstract

The role of antibody-mediated rejection in acute and chronic rejection after lung transplantation is poorly understood. We report the case of a prior single-lung transplant recipient undergoing an acute antibody-mediated rejection isolated to her new, contralateral single-lung transplant. A 44-year-old woman 6 years after undergoing a single-lung transplant for idiopathic pulmonary fibrosis underwent a second single-lung transplant for bronchiolitis obliterans syndrome. Despite a negative crossmatch, she subsequently exhibited severe antibody-mediated rejection to her new allograft within 6 days of transplantation. The process of allograft sensitization is dynamic, and further study is warranted to better understand this process.

Original languageEnglish (US)
JournalAnnals of Thoracic Surgery
Volume95
Issue number4
DOIs
StatePublished - Apr 2013

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Transplants
Lung
Allografts
Antibodies
Bronchiolitis Obliterans
Idiopathic Pulmonary Fibrosis
Lung Transplantation
Transplantation
Transplant Recipients

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Unilateral humoral rejection after reoperative single-lung transplant. / Beaty, Claude A.; Yang, Alexander; George, Timothy J.; Illei, Peter B; Shah, Ashish S.

In: Annals of Thoracic Surgery, Vol. 95, No. 4, 04.2013.

Research output: Contribution to journalArticle

Beaty, Claude A. ; Yang, Alexander ; George, Timothy J. ; Illei, Peter B ; Shah, Ashish S. / Unilateral humoral rejection after reoperative single-lung transplant. In: Annals of Thoracic Surgery. 2013 ; Vol. 95, No. 4.
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