Unilateral and bilateral expression of a quantitative trait: Asymmetry and symmetry in coronal craniosynostosis

Yann Heuzé, Neus Martínez-Abadías, Jennifer M. Stella, Craig W. Senders, Simeon A. Boyadjiev, Lun Jou Lo, Joan T. Richtsmeier

Research output: Research - peer-reviewArticle

Abstract

Bilateral symmetry in vertebrates is imperfect and mild asymmetries are found in normal growth and development. However, abnormal development is often characterized by strong asymmetries. Coronal craniosynostosis, defined here as consisting of premature suture closure and a characteristic skull shape, is a complex trait. The premature fusion of the coronal suture can occur unilaterally associated with skull asymmetry (anterior plagiocephaly) or bilaterally associated with a symmetric but brachycephalic skull. We investigated the relationship between coronal craniosynostosis and skull bilateral symmetry. Three-dimensional landmark coordinates were recorded on preoperative computed tomography images of children diagnosed with coronal nonsyndromic craniosynostosis (N = 40) and that of unaffected individuals (N = 20) and analyzed by geometric morphometrics. Our results showed that the fusion pattern of the coronal suture is similar across individuals and types of coronal craniosynostosis. Shape analysis showed that skulls of bilateral coronal craniosynostosis (BCS) and unaffected individuals display low degrees of asymmetry, whereas right and left unilateral coronal craniosynostosis (UCS) skulls are asymmetric and mirror images of one another. When premature fusion of the coronal suture (without taking into account cranial dysmorphology) is scored as a qualitative trait, the expected relationship between trait frequency and trait unilateral expression (i.e. negative correlation) is confirmed. Overall, we interpret our results as evidence that the same biological processes operate on the two sides in BCS skulls and on the affected side in UCS skulls, and that coronal craniosynostosis is a quantitative trait exhibiting a phenotypic continuum with BCS displaying more intense shape changes than UCS. J. Exp. Zool. (Mol. Dev. Evol.) 314B, 2011.

LanguageEnglish (US)
JournalJournal of Experimental Zoology Part B: Molecular and Developmental Evolution
DOIs
StateAccepted/In press - 1800
Externally publishedYes

Fingerprint

skull
symmetry
asymmetry
quantitative traits
Craniosynostoses
Fusion reactions
Skull
sutures
Sutures
Tomography
Mirrors
shape analysis
growth and development
biological processes
tomography
vertebrate
abnormal development
computed tomography
vertebrates
Plagiocephaly

ASJC Scopus subject areas

  • Organic Chemistry
  • Inorganic Chemistry
  • Waste Management and Disposal
  • Developmental Biology
  • Genetics
  • Molecular Medicine
  • Ecology, Evolution, Behavior and Systematics
  • Animal Science and Zoology

Cite this

Unilateral and bilateral expression of a quantitative trait : Asymmetry and symmetry in coronal craniosynostosis. / Heuzé, Yann; Martínez-Abadías, Neus; Stella, Jennifer M.; Senders, Craig W.; Boyadjiev, Simeon A.; Lo, Lun Jou; Richtsmeier, Joan T.

In: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 1800.

Research output: Research - peer-reviewArticle

Heuzé, Yann ; Martínez-Abadías, Neus ; Stella, Jennifer M. ; Senders, Craig W. ; Boyadjiev, Simeon A. ; Lo, Lun Jou ; Richtsmeier, Joan T./ Unilateral and bilateral expression of a quantitative trait : Asymmetry and symmetry in coronal craniosynostosis. In: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 1800
@article{7fb5c9a12b7a431a99d493f961d5d978,
title = "Unilateral and bilateral expression of a quantitative trait: Asymmetry and symmetry in coronal craniosynostosis",
abstract = "Bilateral symmetry in vertebrates is imperfect and mild asymmetries are found in normal growth and development. However, abnormal development is often characterized by strong asymmetries. Coronal craniosynostosis, defined here as consisting of premature suture closure and a characteristic skull shape, is a complex trait. The premature fusion of the coronal suture can occur unilaterally associated with skull asymmetry (anterior plagiocephaly) or bilaterally associated with a symmetric but brachycephalic skull. We investigated the relationship between coronal craniosynostosis and skull bilateral symmetry. Three-dimensional landmark coordinates were recorded on preoperative computed tomography images of children diagnosed with coronal nonsyndromic craniosynostosis (N = 40) and that of unaffected individuals (N = 20) and analyzed by geometric morphometrics. Our results showed that the fusion pattern of the coronal suture is similar across individuals and types of coronal craniosynostosis. Shape analysis showed that skulls of bilateral coronal craniosynostosis (BCS) and unaffected individuals display low degrees of asymmetry, whereas right and left unilateral coronal craniosynostosis (UCS) skulls are asymmetric and mirror images of one another. When premature fusion of the coronal suture (without taking into account cranial dysmorphology) is scored as a qualitative trait, the expected relationship between trait frequency and trait unilateral expression (i.e. negative correlation) is confirmed. Overall, we interpret our results as evidence that the same biological processes operate on the two sides in BCS skulls and on the affected side in UCS skulls, and that coronal craniosynostosis is a quantitative trait exhibiting a phenotypic continuum with BCS displaying more intense shape changes than UCS. J. Exp. Zool. (Mol. Dev. Evol.) 314B, 2011.",
author = "Yann Heuzé and Neus Martínez-Abadías and Stella, {Jennifer M.} and Senders, {Craig W.} and Boyadjiev, {Simeon A.} and Lo, {Lun Jou} and Richtsmeier, {Joan T.}",
year = "1800",
doi = "10.1002/jez.b.21449",
journal = "Journal of Experimental Zoology Part B: Molecular and Developmental Evolution",
issn = "1552-5007",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Unilateral and bilateral expression of a quantitative trait

T2 - Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

AU - Heuzé,Yann

AU - Martínez-Abadías,Neus

AU - Stella,Jennifer M.

AU - Senders,Craig W.

AU - Boyadjiev,Simeon A.

AU - Lo,Lun Jou

AU - Richtsmeier,Joan T.

PY - 1800

Y1 - 1800

N2 - Bilateral symmetry in vertebrates is imperfect and mild asymmetries are found in normal growth and development. However, abnormal development is often characterized by strong asymmetries. Coronal craniosynostosis, defined here as consisting of premature suture closure and a characteristic skull shape, is a complex trait. The premature fusion of the coronal suture can occur unilaterally associated with skull asymmetry (anterior plagiocephaly) or bilaterally associated with a symmetric but brachycephalic skull. We investigated the relationship between coronal craniosynostosis and skull bilateral symmetry. Three-dimensional landmark coordinates were recorded on preoperative computed tomography images of children diagnosed with coronal nonsyndromic craniosynostosis (N = 40) and that of unaffected individuals (N = 20) and analyzed by geometric morphometrics. Our results showed that the fusion pattern of the coronal suture is similar across individuals and types of coronal craniosynostosis. Shape analysis showed that skulls of bilateral coronal craniosynostosis (BCS) and unaffected individuals display low degrees of asymmetry, whereas right and left unilateral coronal craniosynostosis (UCS) skulls are asymmetric and mirror images of one another. When premature fusion of the coronal suture (without taking into account cranial dysmorphology) is scored as a qualitative trait, the expected relationship between trait frequency and trait unilateral expression (i.e. negative correlation) is confirmed. Overall, we interpret our results as evidence that the same biological processes operate on the two sides in BCS skulls and on the affected side in UCS skulls, and that coronal craniosynostosis is a quantitative trait exhibiting a phenotypic continuum with BCS displaying more intense shape changes than UCS. J. Exp. Zool. (Mol. Dev. Evol.) 314B, 2011.

AB - Bilateral symmetry in vertebrates is imperfect and mild asymmetries are found in normal growth and development. However, abnormal development is often characterized by strong asymmetries. Coronal craniosynostosis, defined here as consisting of premature suture closure and a characteristic skull shape, is a complex trait. The premature fusion of the coronal suture can occur unilaterally associated with skull asymmetry (anterior plagiocephaly) or bilaterally associated with a symmetric but brachycephalic skull. We investigated the relationship between coronal craniosynostosis and skull bilateral symmetry. Three-dimensional landmark coordinates were recorded on preoperative computed tomography images of children diagnosed with coronal nonsyndromic craniosynostosis (N = 40) and that of unaffected individuals (N = 20) and analyzed by geometric morphometrics. Our results showed that the fusion pattern of the coronal suture is similar across individuals and types of coronal craniosynostosis. Shape analysis showed that skulls of bilateral coronal craniosynostosis (BCS) and unaffected individuals display low degrees of asymmetry, whereas right and left unilateral coronal craniosynostosis (UCS) skulls are asymmetric and mirror images of one another. When premature fusion of the coronal suture (without taking into account cranial dysmorphology) is scored as a qualitative trait, the expected relationship between trait frequency and trait unilateral expression (i.e. negative correlation) is confirmed. Overall, we interpret our results as evidence that the same biological processes operate on the two sides in BCS skulls and on the affected side in UCS skulls, and that coronal craniosynostosis is a quantitative trait exhibiting a phenotypic continuum with BCS displaying more intense shape changes than UCS. J. Exp. Zool. (Mol. Dev. Evol.) 314B, 2011.

UR - http://www.scopus.com/inward/record.url?scp=80054864830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054864830&partnerID=8YFLogxK

U2 - 10.1002/jez.b.21449

DO - 10.1002/jez.b.21449

M3 - Article

JO - Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

JF - Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

SN - 1552-5007

ER -