Uniform spinning sampling gradient electron paramagnetic resonance imaging

David H. Johnson, Rizwan Ahmad, Yangping Liu, Zhiyu Chen, Alexandre Samouilov, Jay L. Zweier

Research output: Contribution to journalArticle

Abstract

Purpose To improve the quality and speed of electron paramagnetic resonance imaging (EPRI) acquisition by combining a uniform sampling distribution with spinning gradient acquisition. Theory and Methods A uniform sampling distribution was derived for spinning gradient EPRI acquisition (uniform spinning sampling, USS) and compared to the existing (equilinear spinning sampling, ESS) acquisition strategy. Novel corrections were introduced to reduce artifacts in experimental data. Results Simulations demonstrated that USS puts an equal number of projections near each axis whereas ESS puts excessive projections at one axis, wasting acquisition time. Artifact corrections added to the magnetic gradient waveforms reduced noise and correlation between projections. USS images had higher SNR (85.9 ± 0.8 vs. 56.2 ± 0.8) and lower mean-squared error than ESS images. The quality of the USS images did not vary with the magnetic gradient orientation, in contrast to ESS images. The quality of rat heart images was improved using USS compared to that with ESS or traditional fast-scan acquisitions. Conclusion A novel EPRI acquisition which combines spinning gradient acquisition with a uniform sampling distribution was developed. This USS spinning gradient acquisition offers superior SNR and reduced artifacts compared to prior methods enabling potential improvements in speed and quality of EPR imaging in biological applications.

Original languageEnglish (US)
Pages (from-to)893-900
Number of pages8
JournalMagnetic Resonance in Medicine
Volume71
Issue number2
DOIs
StatePublished - Feb 2014
Externally publishedYes

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Electron Spin Resonance Spectroscopy
Artifacts
Noise

Keywords

  • electron paramagnetic resonance imaging
  • free radicals
  • image reconstruction
  • paramagnetic probes
  • spinning magnetic field gradient

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Johnson, D. H., Ahmad, R., Liu, Y., Chen, Z., Samouilov, A., & Zweier, J. L. (2014). Uniform spinning sampling gradient electron paramagnetic resonance imaging. Magnetic Resonance in Medicine, 71(2), 893-900. https://doi.org/10.1002/mrm.24712

Uniform spinning sampling gradient electron paramagnetic resonance imaging. / Johnson, David H.; Ahmad, Rizwan; Liu, Yangping; Chen, Zhiyu; Samouilov, Alexandre; Zweier, Jay L.

In: Magnetic Resonance in Medicine, Vol. 71, No. 2, 02.2014, p. 893-900.

Research output: Contribution to journalArticle

Johnson, DH, Ahmad, R, Liu, Y, Chen, Z, Samouilov, A & Zweier, JL 2014, 'Uniform spinning sampling gradient electron paramagnetic resonance imaging', Magnetic Resonance in Medicine, vol. 71, no. 2, pp. 893-900. https://doi.org/10.1002/mrm.24712
Johnson, David H. ; Ahmad, Rizwan ; Liu, Yangping ; Chen, Zhiyu ; Samouilov, Alexandre ; Zweier, Jay L. / Uniform spinning sampling gradient electron paramagnetic resonance imaging. In: Magnetic Resonance in Medicine. 2014 ; Vol. 71, No. 2. pp. 893-900.
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