Uniform platelet activation exists before coronary stent implantation despite aspirin therapy

Victor L. Serebruany, Charles C. Cummings, Alex I. Malinin, Steven R. Steinhubl, Paul A. Gurbel

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Platelets play an important role in the natural history of coronary artery disease. Enhanced platelet aggregation and receptor expression unquestionably occur after coronary stent implantation; however, the functional characteristics of platelets before stenting have not been fully elucidated. Methods: Platelets were assessed before intervention by platelet-rich plasma aggregation (PA) with 5 μmol adenosine diphosphate (ADP) and 1 μg/mL collagen; whole blood aggregation (WBA) by 1 μg/mL collagen; shear-induced closure time (CT); contractile force (CF); and expression of 9 surface receptors by flow cytometry in 126 patients undergoing elective coronary artery stent placement. All patients received aspirin for at least 7 days. The data were compared with those from 64 healthy volunteers. Results: Each test revealed sustained platelet activation in patients undergoing coronary stenting compared with control values. These differences were significant for collagen-induced PA (P = .031); CF (P = .0001); expression of glycoprotein (GP) IIb/IIIa (P = .0001); P-selectin (P = .0008); platelet/endothelial cell adhesion molecule (PECAM)-1 (P = .0001); CD107a (P = .0001); CD107b (P = .0004); and CD63 (P = .009). Conclusion: Platelets are indeed activated before coronary stenting despite antecedent therapy with aspirin.

Original languageEnglish (US)
Pages (from-to)611-616
Number of pages6
JournalAmerican heart journal
Volume142
Issue number4
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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