TY - JOUR
T1 - Uniform platelet activation exists before coronary stent implantation despite aspirin therapy
AU - Serebruany, Victor L.
AU - Cummings, Charles C.
AU - Malinin, Alex I.
AU - Steinhubl, Steven R.
AU - Gurbel, Paul A.
N1 - Funding Information:
Supported in part by Sanofi Synthelabo. We are also indebted to the staff of the Cardiac Catheterization Laboratory at Sinai Hospital.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - Background: Platelets play an important role in the natural history of coronary artery disease. Enhanced platelet aggregation and receptor expression unquestionably occur after coronary stent implantation; however, the functional characteristics of platelets before stenting have not been fully elucidated. Methods: Platelets were assessed before intervention by platelet-rich plasma aggregation (PA) with 5 μmol adenosine diphosphate (ADP) and 1 μg/mL collagen; whole blood aggregation (WBA) by 1 μg/mL collagen; shear-induced closure time (CT); contractile force (CF); and expression of 9 surface receptors by flow cytometry in 126 patients undergoing elective coronary artery stent placement. All patients received aspirin for at least 7 days. The data were compared with those from 64 healthy volunteers. Results: Each test revealed sustained platelet activation in patients undergoing coronary stenting compared with control values. These differences were significant for collagen-induced PA (P = .031); CF (P = .0001); expression of glycoprotein (GP) IIb/IIIa (P = .0001); P-selectin (P = .0008); platelet/endothelial cell adhesion molecule (PECAM)-1 (P = .0001); CD107a (P = .0001); CD107b (P = .0004); and CD63 (P = .009). Conclusion: Platelets are indeed activated before coronary stenting despite antecedent therapy with aspirin.
AB - Background: Platelets play an important role in the natural history of coronary artery disease. Enhanced platelet aggregation and receptor expression unquestionably occur after coronary stent implantation; however, the functional characteristics of platelets before stenting have not been fully elucidated. Methods: Platelets were assessed before intervention by platelet-rich plasma aggregation (PA) with 5 μmol adenosine diphosphate (ADP) and 1 μg/mL collagen; whole blood aggregation (WBA) by 1 μg/mL collagen; shear-induced closure time (CT); contractile force (CF); and expression of 9 surface receptors by flow cytometry in 126 patients undergoing elective coronary artery stent placement. All patients received aspirin for at least 7 days. The data were compared with those from 64 healthy volunteers. Results: Each test revealed sustained platelet activation in patients undergoing coronary stenting compared with control values. These differences were significant for collagen-induced PA (P = .031); CF (P = .0001); expression of glycoprotein (GP) IIb/IIIa (P = .0001); P-selectin (P = .0008); platelet/endothelial cell adhesion molecule (PECAM)-1 (P = .0001); CD107a (P = .0001); CD107b (P = .0004); and CD63 (P = .009). Conclusion: Platelets are indeed activated before coronary stenting despite antecedent therapy with aspirin.
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U2 - 10.1067/mhj.2001.116478
DO - 10.1067/mhj.2001.116478
M3 - Article
C2 - 11579350
AN - SCOPUS:0034808129
SN - 0002-8703
VL - 142
SP - 611
EP - 616
JO - American heart journal
JF - American heart journal
IS - 4
ER -