Unified mechanisms of Ca2+ regulation across the Ca 2+ channel family

Haoya Liang, Carla D. DeMaria, Michael G. Erickson, Masayuki X. Mori, Badr A. Alseikhan, David T. Yue

Research output: Contribution to journalArticlepeer-review

Abstract

L-type (CaV1.2) and P/Q-type (CaV2.1) calcium channels possess lobe-specific CaM regulation, where Ca2+ binding to one or the other lobe of CaM triggers regulation, even with inverted polarity of modulation between channels. Other major members of the CaV1-2 channel family, R-type (CaV2.3) and N-type (CaV2.2), have appeared to lack such CaM regulation. We report here that R- and N-type channels undergo Ca2+-dependent inactivation, which is mediated by the CaM N-terminal lobe and present only with mild Ca2+ buffering (0.5 mM EGTA) characteristic of many neurons. These features, together with the CaM regulatory profiles of L- and P/Q-type channels, are consistent with a simplifying principle for CaM signal detection in CaV1-2 channels - independent of channel context, the N- and C-terminal lobes of CaM appear invariably specialized for decoding local versus global Ca2+ activity, respectively.

Original languageEnglish (US)
Pages (from-to)951-960
Number of pages10
JournalNeuron
Volume39
Issue number6
DOIs
StatePublished - Sep 11 2003

ASJC Scopus subject areas

  • Neuroscience(all)

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