@article{eca17adcb51b4d9ab9b8dba69eb11264,
title = "Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men",
abstract = "BACKGROUND: Approximately 10% of incident TB cases worldwide are attributable to alcohol. However, evidence associating alcohol with unfavorable TB treatment outcomes is weak. METHODS: We prospectively evaluated men (>18 years) with pulmonary TB in India for up to 24 months to investigate the association between alcohol use and treatment outcomes. Unhealthy alcohol use was defined as a score of >4 on the Alcohol Use Disorders Identification Test-Concise (AUDIT-C) scale at entry. Unfavorable TB treatment outcomes included failure, recurrence, and all-cause mortality, analyzed as composite and independent endpoints. R E S U LT S: Among 751 men, we identified unhealthy alcohol use in 302 (40%). Median age was 39 years (IQR 28-50); 415 (55%) were underweight (defined as a body mass index [BMI],18.5 kg/m2); and 198 (26%) experienced an unfavorable outcome. Unhealthy alcohol use was an independent risk factor for the composite unfavorable outcome (adjusted incidence rate ratio [aIRR] 1.47, 95% CI 1.05-2.06; P¼0.03) and death (aIRR 1.90, 95% CI 1.08-3.34; P¼ 0.03), specifically. We found significant interaction between AUDIT-C and BMI; underweight men with unhealthy alcohol use had increased risk of unfavorable outcomes (aIRR 2.22, 95% CI 1.44-3.44; P, 0.001) compared to men with BMI >18.5 kg/m2 and AUDIT-C,4. CONCLUSION: Unhealthy alcohol use was independently associated with unfavorable TB treatment outcomes, highlighting the need for integrating effective alcohol interventions into TB care.",
keywords = "AUDIT, Adverse outcomes, Failure, Mortality, Recurrence",
author = "Cox, {S. R.} and Gupte, {A. N.} and B. Thomas and S. Gaikwad and V. Mave and C. Padmapriyadarsini and Sahasrabudhe, {T. R.} and D. Kadam and N. Gupte and Hanna, {L. E.} and A. Kagal and M. Paradkar and K. Thiruvengadam and D. Jain and S. Atre and K. Sekar and S. Raskar and Shivakumar, {S. V.B.Y.} and R. Santhappan and S. Deshmukh and N. Pradhan and V. Kulkarni and A. Kakrani and Barthwal, {M. S.} and T. Sawant and A. DeLuca and N. Suryavanshi and G. Chander and R. Bollinger and Golub, {J. E.} and A. Gupta",
note = "Funding Information: The authors would like to sincerely thank the study participants and study staff; and M B Arriaga-Gutierrez and B Andrade from the Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) group who helped develop the figures. This work was supported by the National Institute of Allergy and Infectious Diseases of the United States National Institutes of Health (Bethesda, MD, USA) [grant numbers #DAA3-18-64774-1 (CRDF Global), R01AI097494]; the Government of India's Department of Biotechnology for the CTRIUMPh Study as part of the Regional Prospective Observational Research for Tuberculosis (RePORT) India Consortium; and Persistent Systems (Pune, India) in kind. Funding Information: This work was supported by the National Institute of Allergy and Infectious Diseases of the United States National Institutes of Health (Bethesda, MD, USA) [grant numbers #DAA3-18-64774-1 (CRDF Global), R01AI097494]; the Government of India{\textquoteright}s Department of Biotechnology for the CTRIUMPh Study as part of the Regional Prospective Observational Research for Tuberculosis (RePORT) India Consortium; and Persistent Systems (Pune, India) in kind. Publisher Copyright: {\textcopyright} 2021 The Union",
year = "2021",
month = mar,
day = "1",
doi = "10.5588/IJTLD.20.0778",
language = "English (US)",
volume = "25",
pages = "182--190",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "3",
}