Abstract
The α-globin of five black Americans, two Chinese, and five Filipinos with HbH disease (an α-thalassemia state in which there is a single functional α gene) were anlyzed by restriction endonuclease techniques. All sujects were found to have one chromosome 16, lacking both α genes, and another containing a single α gene (--/-α). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single α gene in these individuals.
Original language | English (US) |
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Pages (from-to) | 1066-1069 |
Number of pages | 4 |
Journal | Blood |
Volume | 55 |
Issue number | 6 |
State | Published - 1980 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology