Unequal crossing-over: A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease

J. A. Phillips, T. A. Vik, A. F. Scott, K. E. Young, H. H. Kazazian, K. D. Smith, V. F. Fairbanks, H. M. Koenig

Research output: Contribution to journalArticlepeer-review

Abstract

The α-globin of five black Americans, two Chinese, and five Filipinos with HbH disease (an α-thalassemia state in which there is a single functional α gene) were anlyzed by restriction endonuclease techniques. All sujects were found to have one chromosome 16, lacking both α genes, and another containing a single α gene (--/-α). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single α gene in these individuals.

Original languageEnglish (US)
Pages (from-to)1066-1069
Number of pages4
JournalBlood
Volume55
Issue number6
StatePublished - Aug 18 1980

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Fingerprint Dive into the research topics of 'Unequal crossing-over: A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease'. Together they form a unique fingerprint.

Cite this