Unequal crossing-over: A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease

J. A. Phillips; T. A. Vik; A. F. Scott; K. E. Young; H. H. Kazazian; K. D. Smith; V. F. Fairbanks; H. M. Koenig

Unequal crossing-over: A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease

J. A. Phillips, T. A. Vik, A. F. Scott, K. E. Young, H. H. Kazazian, K. D. Smith, V. F. Fairbanks, H. M. Koenig

School of Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The α-globin of five black Americans, two Chinese, and five Filipinos with HbH disease (an α-thalassemia state in which there is a single functional α gene) were anlyzed by restriction endonuclease techniques. All sujects were found to have one chromosome 16, lacking both α genes, and another containing a single α gene (--/-α). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single α gene in these individuals.

Original language	English (US)
Pages (from-to)	1066-1069
Number of pages	4
Journal	Blood
Volume	55
Issue number	6
State	Published - 1980

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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title = "Unequal crossing-over: A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease",

abstract = "The α-globin of five black Americans, two Chinese, and five Filipinos with HbH disease (an α-thalassemia state in which there is a single functional α gene) were anlyzed by restriction endonuclease techniques. All sujects were found to have one chromosome 16, lacking both α genes, and another containing a single α gene (--/-α). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single α gene in these individuals.",

author = "Phillips, {J. A.} and Vik, {T. A.} and Scott, {A. F.} and Young, {K. E.} and Kazazian, {H. H.} and Smith, {K. D.} and Fairbanks, {V. F.} and Koenig, {H. M.}",

year = "1980",

language = "English (US)",

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pages = "1066--1069",

journal = "Blood",

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publisher = "American Society of Hematology",

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T1 - Unequal crossing-over

T2 - A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease

AU - Phillips, J. A.

AU - Vik, T. A.

AU - Scott, A. F.

AU - Young, K. E.

AU - Kazazian, H. H.

AU - Smith, K. D.

AU - Fairbanks, V. F.

AU - Koenig, H. M.

PY - 1980

Y1 - 1980

N2 - The α-globin of five black Americans, two Chinese, and five Filipinos with HbH disease (an α-thalassemia state in which there is a single functional α gene) were anlyzed by restriction endonuclease techniques. All sujects were found to have one chromosome 16, lacking both α genes, and another containing a single α gene (--/-α). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single α gene in these individuals.

AB - The α-globin of five black Americans, two Chinese, and five Filipinos with HbH disease (an α-thalassemia state in which there is a single functional α gene) were anlyzed by restriction endonuclease techniques. All sujects were found to have one chromosome 16, lacking both α genes, and another containing a single α gene (--/-α). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single α gene in these individuals.

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SN - 0006-4971

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JO - Blood

JF - Blood

IS - 6

ER -

Unequal crossing-over: A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease

Abstract

ASJC Scopus subject areas

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