Abstract
The HIV Prevention Trials Network 052 study enrolled serodiscordant couples. Index participants infected with human immunodeficiency virus reported no prior antiretroviral (ARV) treatment at enrollment. ARV drug testing was performed retrospectively using enrollment samples from a subset of index participants. ARV drugs were detected in 45 of 96 participants (46.9%) with an undetectable viral load, 2 of 48 (4.2%) with a low viral load, and 1 of 65 (1.5%) with a high viral load (P <.0001); they were also detected in follow-up samples from participants who were not receiving study-administered treatment. ARV drug testing may be useful in addition to selfreport of ARV drug use in some clinical trial settings.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1624-1628 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 208 |
| Issue number | 10 |
| DOIs | |
| State | Published - Nov 15 2013 |
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Keywords
- Africa
- Antiretroviral drug
- Clinical trial
- HIV
- HPTN 052
- Self-report
ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Allergy
Cite this
Undisclosed antiretroviral drug use in a multinational clinical trial (HIV prevention trials network 052). / Fogel, Jessica Marie Louise; Wang, Lei; Parsons, Teresa L.; Ou, San San; Piwowar-Manning, Estelle; Chen, Ying; Mudhune, Victor O.; Hosseinipour, Mina C.; Kumwenda, Johnstone; Hakim, James G.; Chariyalertsak, Suwat; Panchia, Ravindre; Sanne, Ian; Kumarasamy, Nagalingeswaran; Grinsztejn, Beatriz; Makhema, Joseph; Pilotto, Jose; Santos, Breno R.; Mayer, Kenneth H.; McCauley, Marybeth; Gamble, Theresa; Bumpus, Namandje N; Hendrix, Craig; Cohen, Myron S.; Eshleman, Susan.
In: Journal of Infectious Diseases, Vol. 208, No. 10, 15.11.2013, p. 1624-1628.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Undisclosed antiretroviral drug use in a multinational clinical trial (HIV prevention trials network 052)
AU - Fogel, Jessica Marie Louise
AU - Wang, Lei
AU - Parsons, Teresa L.
AU - Ou, San San
AU - Piwowar-Manning, Estelle
AU - Chen, Ying
AU - Mudhune, Victor O.
AU - Hosseinipour, Mina C.
AU - Kumwenda, Johnstone
AU - Hakim, James G.
AU - Chariyalertsak, Suwat
AU - Panchia, Ravindre
AU - Sanne, Ian
AU - Kumarasamy, Nagalingeswaran
AU - Grinsztejn, Beatriz
AU - Makhema, Joseph
AU - Pilotto, Jose
AU - Santos, Breno R.
AU - Mayer, Kenneth H.
AU - McCauley, Marybeth
AU - Gamble, Theresa
AU - Bumpus, Namandje N
AU - Hendrix, Craig
AU - Cohen, Myron S.
AU - Eshleman, Susan
PY - 2013/11/15
Y1 - 2013/11/15
N2 - The HIV Prevention Trials Network 052 study enrolled serodiscordant couples. Index participants infected with human immunodeficiency virus reported no prior antiretroviral (ARV) treatment at enrollment. ARV drug testing was performed retrospectively using enrollment samples from a subset of index participants. ARV drugs were detected in 45 of 96 participants (46.9%) with an undetectable viral load, 2 of 48 (4.2%) with a low viral load, and 1 of 65 (1.5%) with a high viral load (P <.0001); they were also detected in follow-up samples from participants who were not receiving study-administered treatment. ARV drug testing may be useful in addition to selfreport of ARV drug use in some clinical trial settings.
AB - The HIV Prevention Trials Network 052 study enrolled serodiscordant couples. Index participants infected with human immunodeficiency virus reported no prior antiretroviral (ARV) treatment at enrollment. ARV drug testing was performed retrospectively using enrollment samples from a subset of index participants. ARV drugs were detected in 45 of 96 participants (46.9%) with an undetectable viral load, 2 of 48 (4.2%) with a low viral load, and 1 of 65 (1.5%) with a high viral load (P <.0001); they were also detected in follow-up samples from participants who were not receiving study-administered treatment. ARV drug testing may be useful in addition to selfreport of ARV drug use in some clinical trial settings.
KW - Africa
KW - Antiretroviral drug
KW - Clinical trial
KW - HIV
KW - HPTN 052
KW - Self-report
UR - http://www.scopus.com/inward/record.url?scp=84888605119&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888605119&partnerID=8YFLogxK
U2 - 10.1093/infdis/jit390
DO - 10.1093/infdis/jit390
M3 - Article
C2 - 23908493
AN - SCOPUS:84888605119
VL - 208
SP - 1624
EP - 1628
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 10
ER -