@article{719b2c101c4c4c3d85c7d8a72a0787ef,
title = "Undisclosed antiretroviral drug use in a multinational clinical trial (HIV prevention trials network 052)",
abstract = "The HIV Prevention Trials Network 052 study enrolled serodiscordant couples. Index participants infected with human immunodeficiency virus reported no prior antiretroviral (ARV) treatment at enrollment. ARV drug testing was performed retrospectively using enrollment samples from a subset of index participants. ARV drugs were detected in 45 of 96 participants (46.9%) with an undetectable viral load, 2 of 48 (4.2%) with a low viral load, and 1 of 65 (1.5%) with a high viral load (P < .0001); they were also detected in follow-up samples from participants who were not receiving study-administered treatment. ARV drug testing may be useful in addition to selfreport of ARV drug use in some clinical trial settings.",
keywords = "Africa, Antiretroviral drug, Clinical trial, HIV, HPTN 052, Self-report",
author = "Fogel, {Jessica Marie Louise} and Lei Wang and Parsons, {Teresa L} and Ou, {San San} and Estelle Piwowar-Manning and Ying Chen and Mudhune, {Victor O.} and Hosseinipour, {Mina C.} and Johnstone Kumwenda and Hakim, {James G.} and Suwat Chariyalertsak and Ravindre Panchia and Ian Sanne and Nagalingeswaran Kumarasamy and Beatriz Grinsztejn and Joseph Makhema and Jose Pilotto and Santos, {Breno R.} and Mayer, {Kenneth H.} and Marybeth McCauley and Theresa Gamble and Bumpus, {Namandj{\'e} N.} and Hendrix, {Craig W.} and Cohen, {Myron S.} and Eshleman, {Susan H.}",
note = "Funding Information: Financial support. This work was supported by the Division of AIDS of the US National Institute of Allergy and Infectious Diseases and the Office of AIDS Research of the US National Institutes of Health (grants U01-AI018136, U01-AI068613/UM1-AI068613, U01-AI068617/UM1-AI068617, and U01-AI068619/UM1-AI068619). Study drugs used in HPTN 052 were donated by Abbott Laboratories, Boehringer-Ingelheim Pharmaceuticals, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline/ ViiV Healthcare, and Merck. Potential conflicts of interest. All authors: No reported conflicts.",
year = "2013",
month = nov,
day = "15",
doi = "10.1093/infdis/jit390",
language = "English (US)",
volume = "208",
pages = "1624--1628",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",
}