Understanding the Surgical Margin: A Molecular Assessment

Research output: Contribution to journalReview articlepeer-review

Abstract

The inclusion of molecular characteristics into surgical margin analysis may not only yield a more sensitive and accurate assessment of the cells in these margins, but may also provide insight into their impacts on patients’ postoperative prognosis. This concept of the “molecular surgical margin” is advantageous, as it integrates recent advances in our understanding of head and neck carcinogenesis, while also retaining the established methodology of histopathology. This multidisciplinary approach may facilitate the development of a uniform criterion for defining the surgical margin, which will likely result in a reduced recurrence rate and improved overall patient survival.

Original languageEnglish (US)
Pages (from-to)245-258
Number of pages14
JournalOral and Maxillofacial Surgery Clinics of North America
Volume29
Issue number3
DOIs
StatePublished - Aug 2017

Keywords

  • Field cancerization
  • Head and neck malignancy
  • Molecular margins
  • p53 mutation

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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