Understanding the MIG6-EGFR Signaling Axis in Lung Tumorigenesis

Evgeny Izumchenko, David Sidransky

Research output: Contribution to journalComment/debatepeer-review

Abstract

With multiple clinical trials under way targeting mutant EGFR in patients with lung cancer, Maity and colleagues address important aspects of a MIG6-EGFR signaling axis using genetically engineered mouse models expressing mutated EGFRs on the MIG6-deficient background. This study extends our understanding of EGFR regulation by MIG6 and reveals that MIG6 antagonizes tumor formation in mutant EGFR-driven lung adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)472-474
Number of pages3
JournalCancer discovery
Volume5
Issue number5
DOIs
StatePublished - May 1 2015

ASJC Scopus subject areas

  • Oncology

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