Understanding the causes and consequences of measles virus persistence

Diane Griffin, Wen Hsuan W. Lin, Ashley N. Nelson

Research output: Contribution to journalReview article

Abstract

Measles is an acute systemic viral disease with initial amplification of infection in lymphoid tissue and subsequent spread over 10-14 days to multiple organs. Failure of the innate response to control initial measles virus (MeV) replication is associated with the ability of MeV to inhibit the induction of type I interferon and interferon-stimulated antiviral genes. Rather, the innate response is characterized by the expression of proteins regulated by nuclear factor kappa B and the inflammasome. With eventual development of the adaptive response, the rash appears with immune cell infiltration into sites of virus replication to initiate the clearance of infectious virus. However, MeV RNA is cleared much more slowly than recoverable infectious virus and remains present in lymphoid tissue for at least 6 months after infection. Persistence of viral RNA and protein suggests persistent low-level replication in lymphoid tissue that may facilitate maturation of the immune response, resulting in lifelong protection from reinfection, while persistence in other tissues (for example, the nervous system) may predispose to development of late disease such as subacute sclerosing panencephalitis. Further studies are needed to identify mechanisms of viral clearance and to understand the relationship between persistence and development of lifelong immunity.

Original languageEnglish (US)
Article number237
JournalF1000Research
Volume7
DOIs
StatePublished - Jan 1 2018

Fingerprint

Measles virus
Lymphoid Tissue
Viruses
Virus Replication
Tissue
Inflammasomes
Subacute Sclerosing Panencephalitis
Interferon Type I
NF-kappa B
Viral RNA
Measles
Viral Proteins
Virus Diseases
Infection
Exanthema
Interferons
Nervous System
Antiviral Agents
Immunity
RNA

Keywords

  • Lymphoid tissue
  • Measles
  • RNA
  • Viruses

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Understanding the causes and consequences of measles virus persistence. / Griffin, Diane; Lin, Wen Hsuan W.; Nelson, Ashley N.

In: F1000Research, Vol. 7, 237, 01.01.2018.

Research output: Contribution to journalReview article

Griffin, Diane ; Lin, Wen Hsuan W. ; Nelson, Ashley N. / Understanding the causes and consequences of measles virus persistence. In: F1000Research. 2018 ; Vol. 7.
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