Understanding protein phosphorylation on a systems level

Jimmy Lin, Zhi Xie, Heng Zhu, Jiang Qian

Research output: Contribution to journalArticle

Abstract

Protein kinase phosphorylation is central to the regulation and control of protein and cellular function. Over the past decade, the development of many high-throughput approaches has revolutionized the understanding of protein phosphorylation and allowed rapid and unbiased surveys of phosphoproteins and phosphorylation events. In addition to this technological advancement, there have also been computational improvements; recent studies on network models of protein phosphorylation have provided many insights into the cellular processes and pathways regulated by phosphorylation. This article gives an overview of experimental and computational techniques for identifying and analyzing protein phosphorylation on a systems level.

Original languageEnglish (US)
Article numberelp045
Pages (from-to)32-42
Number of pages11
JournalBriefings in Functional Genomics and Proteomics
Volume9
Issue number1
DOIs
StatePublished - Jan 7 2010

Keywords

  • Kinase
  • Mass spectrometry
  • Phosphoprotein
  • Protein microarray
  • Protein phosphorylation
  • Systems biology

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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