Understanding microRNAs in neurodegeneration

Stephen M. Eacker; Ted M. Dawson; Valina L. Dawson

doi:10.1038/nrn2726

Understanding microRNAs in neurodegeneration

Stephen M. Eacker, Ted M. Dawson, Valina L. Dawson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

213 Scopus citations

Abstract

Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.

Original language	English (US)
Pages (from-to)	837-841
Number of pages	5
Journal	Nature Reviews Neuroscience
Volume	10
Issue number	12
DOIs	https://doi.org/10.1038/nrn2726
State	Published - Dec 2009

ASJC Scopus subject areas

General Neuroscience

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title = "Understanding microRNAs in neurodegeneration",

abstract = "Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.",

author = "Eacker, {Stephen M.} and Dawson, {Ted M.} and Dawson, {Valina L.}",

note = "Funding Information: We apologize to authors whose papers were not discussed here owing to the short format. This work was funded by United States Public Health Service grant DA00266. T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases at the Johns Hopkins University School of Medicine.",

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AU - Dawson, Ted M.

AU - Dawson, Valina L.

N1 - Funding Information: We apologize to authors whose papers were not discussed here owing to the short format. This work was funded by United States Public Health Service grant DA00266. T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases at the Johns Hopkins University School of Medicine.

PY - 2009/12

Y1 - 2009/12

N2 - Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.

AB - Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.

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Understanding microRNAs in neurodegeneration

Abstract

ASJC Scopus subject areas

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