Understanding Frailty, Aging, and Inflammation in HIV Infection

Sean X. Leng; Joseph B. Margolick

doi:10.1007/s11904-014-0247-3

Understanding Frailty, Aging, and Inflammation in HIV Infection

Sean X. Leng, Joseph B. Margolick

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Frailty is a clinical syndrome initially characterized in geriatric populations with a hallmark of age-related declines in physiologic reserve and function and increased vulnerability to adverse health outcomes. Recently, frailty has increasingly been recognized as a common and important HIV-associated non-AIDS (HANA) condition. This article provides an overview of our current understanding of frailty and its phenotypic characteristics and evidence that they are related to aging and to chronic inflammation that is associated with aging and also with long-term treated HIV infection. The etiology of this chronic inflammation is unknown but we discuss evidence linking it to persistent infection with cytomegalovirus in both geriatric populations and people living with HIV infection.

Original language	English (US)
Pages (from-to)	25-32
Number of pages	8
Journal	Current HIV/AIDS reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1007/s11904-014-0247-3
State	Published - Mar 22 2015

Keywords

CMV infection
Frailty
HIV infection
IL-6
Inflammation
T cell immunity

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1007/s11904-014-0247-3

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abstract = "Frailty is a clinical syndrome initially characterized in geriatric populations with a hallmark of age-related declines in physiologic reserve and function and increased vulnerability to adverse health outcomes. Recently, frailty has increasingly been recognized as a common and important HIV-associated non-AIDS (HANA) condition. This article provides an overview of our current understanding of frailty and its phenotypic characteristics and evidence that they are related to aging and to chronic inflammation that is associated with aging and also with long-term treated HIV infection. The etiology of this chronic inflammation is unknown but we discuss evidence linking it to persistent infection with cytomegalovirus in both geriatric populations and people living with HIV infection.",

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AB - Frailty is a clinical syndrome initially characterized in geriatric populations with a hallmark of age-related declines in physiologic reserve and function and increased vulnerability to adverse health outcomes. Recently, frailty has increasingly been recognized as a common and important HIV-associated non-AIDS (HANA) condition. This article provides an overview of our current understanding of frailty and its phenotypic characteristics and evidence that they are related to aging and to chronic inflammation that is associated with aging and also with long-term treated HIV infection. The etiology of this chronic inflammation is unknown but we discuss evidence linking it to persistent infection with cytomegalovirus in both geriatric populations and people living with HIV infection.

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Understanding Frailty, Aging, and Inflammation in HIV Infection

Abstract

Keywords

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