Understanding Frailty, Aging, and Inflammation in HIV Infection

Research output: Contribution to journalReview article

Abstract

Frailty is a clinical syndrome initially characterized in geriatric populations with a hallmark of age-related declines in physiologic reserve and function and increased vulnerability to adverse health outcomes. Recently, frailty has increasingly been recognized as a common and important HIV-associated non-AIDS (HANA) condition. This article provides an overview of our current understanding of frailty and its phenotypic characteristics and evidence that they are related to aging and to chronic inflammation that is associated with aging and also with long-term treated HIV infection. The etiology of this chronic inflammation is unknown but we discuss evidence linking it to persistent infection with cytomegalovirus in both geriatric populations and people living with HIV infection.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalCurrent HIV/AIDS reports
Volume12
Issue number1
DOIs
StatePublished - Mar 22 2015

Keywords

  • CMV infection
  • Frailty
  • HIV infection
  • IL-6
  • Inflammation
  • T cell immunity

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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