Understanding and targeting the Rho kinase pathway in erectile dysfunction

Nikolai A. Sopko, Johanna L. Hannan, Trinity Bivalacqua

Research output: Contribution to journalArticle

Abstract

Erectile dysfunction (ED) is a common disorder that affects a quarter of US men, and has many causes, including endothelial impairment, low testosterone levels, prior surgical manipulation, and/or psychogenic components. Penile erection is a complex process requiring neurally mediated relaxation of arteriolar smooth muscle and engorgement of cavernosal tissues, mediated by nitric oxide (NO). Current medical therapies for ED largely seek to maximize endogenous NO signalling. Certain aetiologies, including diabetes, are difficult to treat with current modalities, emphasizing the need for new molecular targets. Research has demonstrated the importance of RhoA-Rho-associated protein kinase (ROCK) signalling in maintaining a flaccid penile state, and inhibition of RhoA-ROCK signalling potentiates smooth-muscle relaxation in an NO-independent manner. The mechanisms and effects of RhoA-ROCK signalling and inhibition suggest that the RhoA-ROCK pathway could prove to be a new therapeutic target for the treatment of ED.

Original languageEnglish (US)
Pages (from-to)622-628
Number of pages7
JournalNature Reviews Urology
Volume11
Issue number11
DOIs
StatePublished - Nov 11 2014

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rho-Associated Kinases
Erectile Dysfunction
Nitric Oxide
Smooth Muscle
Penile Erection
Muscle Relaxation
Protein Kinases
Testosterone
Therapeutics
Research
Inhibition (Psychology)

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

Cite this

Understanding and targeting the Rho kinase pathway in erectile dysfunction. / Sopko, Nikolai A.; Hannan, Johanna L.; Bivalacqua, Trinity.

In: Nature Reviews Urology, Vol. 11, No. 11, 11.11.2014, p. 622-628.

Research output: Contribution to journalArticle

Sopko, Nikolai A. ; Hannan, Johanna L. ; Bivalacqua, Trinity. / Understanding and targeting the Rho kinase pathway in erectile dysfunction. In: Nature Reviews Urology. 2014 ; Vol. 11, No. 11. pp. 622-628.
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