Under-Reporting of Known HIV-Positive Status Among People Living with HIV: A Systematic Review and Meta-analysis

Nirali Soni, Katia Giguère, Marie Claude Boily, Jessica Marie Louise Fogel, Mathieu Maheu-Giroux, Dobromir Dimitrov, Susan H. Eshleman, Kate M. Mitchell

Research output: Contribution to journalArticlepeer-review

Abstract

Monitoring progress towards the UNAIDS ‘first 90’ target requires accurate estimates of levels of diagnosis among people living with HIV (PLHIV), which is often estimated using self-report. We conducted a systematic review and meta-analysis quantifying under-reporting of known HIV-positive status using objective knowledge proxies. Databases were searched for studies providing self-reported and biological/clinical markers of prior knowledge of HIV-positive status among PLHIV. Random-effects models were used to derive pooled estimates of levels of under-reporting. Thirty-two estimates from 26 studies were included (41,465 PLHIV). The pooled proportion under-reporting known HIV-positive status was 20% (95% confidence interval 13–26%, I2 = 99%). In sub-group analysis, under-reporting was higher among men who have sex with men (32%, number of estimates [Ne] = 10) compared to the general population (9%, Ne = 10) and among Black (18%, Ne = 5) than non-Black (3%, Ne = 3) individuals. Supplementing self-reported data with biological/clinical proxies may improve the validity of the ‘first 90’ estimates.

Original languageEnglish (US)
Pages (from-to)3858-3870
Number of pages13
JournalAIDS and behavior
Volume25
Issue number12
DOIs
StatePublished - Dec 2021

Keywords

  • Bias
  • HIV status
  • Knowledge
  • Proxy
  • Under-report

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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