Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Tu Nguyen, Brian James Kirsch, Ryoichi Asaka, Karim Nabi, Addison Quinones, Jessica Tan, Marjorie Justine Antonio, Felipe Camelo, Ting Li, Stephanie Nguyen, Giang Hoang, Kiet Nguyen, Sunag Udupa, Christos Sazeides, Yao An Shen, Amira Elgogary, Juvenal Reyes, Liang Zhao, Andre Kleensang, Kaisorn Lee ChaichanaThomas Hartung, Michael J. Betenbaugh, Suely K. Marie, Jin G. Jung, Tian-Li Wang, Edward Gabrielson, Quy Hoa Le Thi

Research output: Contribution to journalArticle

Abstract

Nguyen et al. show that NAAG is more abundant in higher grade cancers and a source of glutamate in cancers expressing GCPII, the enzyme that hydrolyzes NAAG to glutamate and NAA. The results suggest that GCPII is a viable target for cancer therapy, either alone or in combination with glutaminase inhibition.

Original languageEnglish (US)
Pages (from-to)491-501.e6
JournalCell Reports
Volume27
Issue number2
DOIs
StatePublished - Apr 9 2019

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Keywords

  • GCPII
  • glutamate carboxypeptidase II
  • glutamate deprivation
  • glutamate reservoir
  • glutaminase inhibitor
  • metabolomics
  • N-acetyl-aspartyl-glutamate
  • NAAG
  • stable isotope resolved

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nguyen, T., Kirsch, B. J., Asaka, R., Nabi, K., Quinones, A., Tan, J., Antonio, M. J., Camelo, F., Li, T., Nguyen, S., Hoang, G., Nguyen, K., Udupa, S., Sazeides, C., Shen, Y. A., Elgogary, A., Reyes, J., Zhao, L., Kleensang, A., ... Le Thi, Q. H. (2019). Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer. Cell Reports, 27(2), 491-501.e6. https://doi.org/10.1016/j.celrep.2019.03.036