Nguyen et al. show that NAAG is more abundant in higher grade cancers and a source of glutamate in cancers expressing GCPII, the enzyme that hydrolyzes NAAG to glutamate and NAA. The results suggest that GCPII is a viable target for cancer therapy, either alone or in combination with glutaminase inhibition.
- glutamate carboxypeptidase II
- glutamate deprivation
- glutamate reservoir
- glutaminase inhibitor
- stable isotope resolved
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)