@article{1f4fb09611004f089c08a1908e9e2ad4,
title = "Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer",
abstract = "Nguyen et al. show that NAAG is more abundant in higher grade cancers and a source of glutamate in cancers expressing GCPII, the enzyme that hydrolyzes NAAG to glutamate and NAA. The results suggest that GCPII is a viable target for cancer therapy, either alone or in combination with glutaminase inhibition.",
keywords = "GCPII, N-acetyl-aspartyl-glutamate, NAAG, glutamate carboxypeptidase II, glutamate deprivation, glutamate reservoir, glutaminase inhibitor, metabolomics, stable isotope resolved",
author = "Tu Nguyen and Kirsch, {Brian James} and Ryoichi Asaka and Karim Nabi and Addison Quinones and Jessica Tan and Antonio, {Marjorie Justine} and Felipe Camelo and Ting Li and Stephanie Nguyen and Giang Hoang and Kiet Nguyen and Sunag Udupa and Christos Sazeides and Shen, {Yao An} and Amira Elgogary and Juvenal Reyes and Liang Zhao and Andre Kleensang and Chaichana, {Kaisorn Lee} and Thomas Hartung and Betenbaugh, {Michael J.} and Marie, {Suely K.} and Jung, {Jin G.} and Wang, {Tian Li} and Edward Gabrielson and Anne Le",
note = "Funding Information: This work was supported by the NIH grants R01-CA193895 , R01-CA112314 , 1S10OD025226-01 , and UL1 TR 001079 ; Hopkins-Allegheny Health Network Cancer Research Fund ; and the Doris M. Weinstein Pancreatic Cancer Research Fund (to A.L.). Special thanks to Michel Soud{\'e}e for his helpful editing. Funding Information: This work was supported by the NIH grants R01-CA193895, R01-CA112314, 1S10OD025226-01, and UL1 TR 001079; Hopkins-Allegheny Health Network Cancer Research Fund; and the Doris M. Weinstein Pancreatic Cancer Research Fund (to A.L.). Special thanks to Michel Soud{\'e}e for his helpful editing. Conceptualization, A.L.; Methodology, T.N. B.J.K. R.A. and A.L.; Investigation, T.N. B.J.K. R.A. K. Nabi, A.Q. J.T. M.J.A. F.C. T.L. S.N. G.H. K. Nguyen, S.U. C.S. Y.-A.S. A.E. J.R. L.Z. and J.G.J.; Writing – Original Draft, T.N. B.J.K. K. Nabi, and A.L.; Writing – Review & Editing, T.N. B.J.K. R.A. J.T. A.Q. E.G. and A.L.; Formal Analysis, T.N. B.J.K. R.A. K. Nabi, A.Q. J.T. M.J.A. F.C. T.L. S.N. G.H. K. Nguyen, S.U. C.S. Y.-A.S. A.E. J.R. L.Z. J.G.J. and A.L.; Supervision, T.N. B.J.K. R.A. J.G.J. and A.L.; Funding Acquisition, A.L.; Resources, L.Z. A.K. T.H. M.J.B. K.L.C. S.K.M. and T.-L.W. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = apr,
day = "9",
doi = "10.1016/j.celrep.2019.03.036",
language = "English (US)",
volume = "27",
pages = "491--501.e6",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",
}