Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Tu Nguyen; Brian James Kirsch; Ryoichi Asaka; Karim Nabi; Addison Quinones; Jessica Tan; Marjorie Justine Antonio; Felipe Camelo; Ting Li; Stephanie Nguyen; Giang Hoang; Kiet Nguyen; Sunag Udupa; Christos Sazeides; Yao An Shen; Amira Elgogary; Juvenal Reyes; Liang Zhao; Andre Kleensang; Kaisorn Lee Chaichana; Thomas Hartung; Michael J. Betenbaugh; Suely K. Marie; Jin G. Jung; Tian Li Wang; Edward Gabrielson; Anne Le

doi:10.1016/j.celrep.2019.03.036

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Tu Nguyen, Brian James Kirsch, Ryoichi Asaka, Karim Nabi, Addison Quinones, Jessica Tan, Marjorie Justine Antonio, Felipe Camelo, Ting Li, Stephanie Nguyen, Giang Hoang, Kiet Nguyen, Sunag Udupa, Christos Sazeides, Yao An Shen, Amira Elgogary, Juvenal Reyes, Liang Zhao, Andre Kleensang, Kaisorn Lee ChaichanaThomas Hartung, Michael J. Betenbaugh, Suely K. Marie, Jin G. Jung, Tian Li Wang, Edward Gabrielson, Anne Le

Research output: Contribution to journal › Article

Abstract

Nguyen et al. show that NAAG is more abundant in higher grade cancers and a source of glutamate in cancers expressing GCPII, the enzyme that hydrolyzes NAAG to glutamate and NAA. The results suggest that GCPII is a viable target for cancer therapy, either alone or in combination with glutaminase inhibition.

Original language	English (US)
Pages (from-to)	491-501.e6
Journal	Cell Reports
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2019.03.036
State	Published - Apr 9 2019

Keywords

GCPII
N-acetyl-aspartyl-glutamate
NAAG
glutamate carboxypeptidase II
glutamate deprivation
glutamate reservoir
glutaminase inhibitor
metabolomics
stable isotope resolved

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.celrep.2019.03.036

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Nguyen, T., Kirsch, B. J., Asaka, R., Nabi, K., Quinones, A., Tan, J., Antonio, M. J., Camelo, F., Li, T., Nguyen, S., Hoang, G., Nguyen, K., Udupa, S., Sazeides, C., Shen, Y. A., Elgogary, A., Reyes, J., Zhao, L., Kleensang, A., ... Le, A. (2019). Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer. Cell Reports, 27(2), 491-501.e6. https://doi.org/10.1016/j.celrep.2019.03.036

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer. / Nguyen, Tu; Kirsch, Brian James; Asaka, Ryoichi; Nabi, Karim; Quinones, Addison; Tan, Jessica; Antonio, Marjorie Justine; Camelo, Felipe; Li, Ting; Nguyen, Stephanie; Hoang, Giang; Nguyen, Kiet; Udupa, Sunag; Sazeides, Christos; Shen, Yao An; Elgogary, Amira; Reyes, Juvenal; Zhao, Liang ; Kleensang, Andre; Chaichana, Kaisorn Lee; Hartung, Thomas; Betenbaugh, Michael J.; Marie, Suely K.; Jung, Jin G.; Wang, Tian Li ; Gabrielson, Edward ; Le, Anne.

In: Cell Reports, Vol. 27, No. 2, 09.04.2019, p. 491-501.e6.

Research output: Contribution to journal › Article

Nguyen, T, Kirsch, BJ, Asaka, R, Nabi, K, Quinones, A, Tan, J, Antonio, MJ, Camelo, F, Li, T, Nguyen, S, Hoang, G, Nguyen, K, Udupa, S, Sazeides, C, Shen, YA, Elgogary, A, Reyes, J, Zhao, L , Kleensang, A, Chaichana, KL, Hartung, T, Betenbaugh, MJ, Marie, SK, Jung, JG, Wang, TL , Gabrielson, E & Le, A 2019, 'Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer', Cell Reports, vol. 27, no. 2, pp. 491-501.e6. https://doi.org/10.1016/j.celrep.2019.03.036

Nguyen, Tu ; Kirsch, Brian James ; Asaka, Ryoichi ; Nabi, Karim ; Quinones, Addison ; Tan, Jessica ; Antonio, Marjorie Justine ; Camelo, Felipe ; Li, Ting ; Nguyen, Stephanie ; Hoang, Giang ; Nguyen, Kiet ; Udupa, Sunag ; Sazeides, Christos ; Shen, Yao An ; Elgogary, Amira ; Reyes, Juvenal ; Zhao, Liang ; Kleensang, Andre ; Chaichana, Kaisorn Lee ; Hartung, Thomas ; Betenbaugh, Michael J. ; Marie, Suely K. ; Jung, Jin G. ; Wang, Tian Li ; Gabrielson, Edward ; Le, Anne. / Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer. In: Cell Reports. 2019 ; Vol. 27, No. 2. pp. 491-501.e6.

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