Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Tu Nguyen; Brian James Kirsch; Ryoichi Asaka; Karim Nabi; Addison Quinones; Jessica Tan; Marjorie Justine Antonio; Felipe Camelo; Ting Li; Stephanie Nguyen; Giang Hoang; Kiet Nguyen; Sunag Udupa; Christos Sazeides; Yao An Shen; Amira Elgogary; Juvenal Reyes; Liang Zhao; Andre Kleensang; Kaisorn Lee Chaichana; Thomas Hartung; Michael J. Betenbaugh; Suely K. Marie; Jin G. Jung; Tian-Li Wang; Edward Gabrielson; Quy Hoa Le Thi

doi:10.1016/j.celrep.2019.03.036

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Tu Nguyen, Brian James Kirsch, Ryoichi Asaka, Karim Nabi, Addison Quinones, Jessica Tan, Marjorie Justine Antonio, Felipe Camelo, Ting Li, Stephanie Nguyen, Giang Hoang, Kiet Nguyen, Sunag Udupa, Christos Sazeides, Yao An Shen, Amira Elgogary, Juvenal Reyes, Liang Zhao, Andre Kleensang, Kaisorn Lee ChaichanaThomas Hartung, Michael J. Betenbaugh, Suely K. Marie, Jin G. Jung, Tian-Li Wang, Edward Gabrielson, Quy Hoa Le Thi

Research output: Contribution to journal › Article

Abstract

Nguyen et al. show that NAAG is more abundant in higher grade cancers and a source of glutamate in cancers expressing GCPII, the enzyme that hydrolyzes NAAG to glutamate and NAA. The results suggest that GCPII is a viable target for cancer therapy, either alone or in combination with glutaminase inhibition.

Original language	English (US)
Pages (from-to)	491-501.e6
Journal	Cell Reports
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2019.03.036
State	Published - Apr 9 2019

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Keywords

GCPII
glutamate carboxypeptidase II
glutamate deprivation
glutamate reservoir
glutaminase inhibitor
metabolomics
N-acetyl-aspartyl-glutamate
NAAG
stable isotope resolved

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nguyen, T., Kirsch, B. J., Asaka, R., Nabi, K., Quinones, A., Tan, J., Antonio, M. J., Camelo, F., Li, T., Nguyen, S., Hoang, G., Nguyen, K., Udupa, S., Sazeides, C., Shen, Y. A., Elgogary, A., Reyes, J., Zhao, L., Kleensang, A., ... Le Thi, Q. H. (2019). Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer. Cell Reports, 27(2), 491-501.e6. https://doi.org/10.1016/j.celrep.2019.03.036

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer. / Nguyen, Tu; Kirsch, Brian James; Asaka, Ryoichi; Nabi, Karim; Quinones, Addison; Tan, Jessica; Antonio, Marjorie Justine; Camelo, Felipe; Li, Ting; Nguyen, Stephanie; Hoang, Giang; Nguyen, Kiet; Udupa, Sunag; Sazeides, Christos; Shen, Yao An; Elgogary, Amira; Reyes, Juvenal; Zhao, Liang ; Kleensang, Andre; Chaichana, Kaisorn Lee; Hartung, Thomas; Betenbaugh, Michael J.; Marie, Suely K.; Jung, Jin G.; Wang, Tian-Li ; Gabrielson, Edward ; Le Thi, Quy Hoa.

In: Cell Reports, Vol. 27, No. 2, 09.04.2019, p. 491-501.e6.

Research output: Contribution to journal › Article

Nguyen, T, Kirsch, BJ, Asaka, R, Nabi, K, Quinones, A, Tan, J, Antonio, MJ, Camelo, F, Li, T, Nguyen, S, Hoang, G, Nguyen, K, Udupa, S, Sazeides, C, Shen, YA, Elgogary, A, Reyes, J, Zhao, L , Kleensang, A, Chaichana, KL, Hartung, T, Betenbaugh, MJ, Marie, SK, Jung, JG, Wang, T-L , Gabrielson, E & Le Thi, QH 2019, 'Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer', Cell Reports, vol. 27, no. 2, pp. 491-501.e6. https://doi.org/10.1016/j.celrep.2019.03.036

Nguyen, Tu ; Kirsch, Brian James ; Asaka, Ryoichi ; Nabi, Karim ; Quinones, Addison ; Tan, Jessica ; Antonio, Marjorie Justine ; Camelo, Felipe ; Li, Ting ; Nguyen, Stephanie ; Hoang, Giang ; Nguyen, Kiet ; Udupa, Sunag ; Sazeides, Christos ; Shen, Yao An ; Elgogary, Amira ; Reyes, Juvenal ; Zhao, Liang ; Kleensang, Andre ; Chaichana, Kaisorn Lee ; Hartung, Thomas ; Betenbaugh, Michael J. ; Marie, Suely K. ; Jung, Jin G. ; Wang, Tian-Li ; Gabrielson, Edward ; Le Thi, Quy Hoa. / Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer. In: Cell Reports. 2019 ; Vol. 27, No. 2. pp. 491-501.e6.

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10.1016/j.celrep.2019.03.036