Abstract
Nguyen et al. show that NAAG is more abundant in higher grade cancers and a source of glutamate in cancers expressing GCPII, the enzyme that hydrolyzes NAAG to glutamate and NAA. The results suggest that GCPII is a viable target for cancer therapy, either alone or in combination with glutaminase inhibition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 491-501.e6 |
| Journal | Cell Reports |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 9 2019 |
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Keywords
- GCPII
- glutamate carboxypeptidase II
- glutamate deprivation
- glutamate reservoir
- glutaminase inhibitor
- metabolomics
- N-acetyl-aspartyl-glutamate
- NAAG
- stable isotope resolved
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer. / Nguyen, Tu; Kirsch, Brian James; Asaka, Ryoichi; Nabi, Karim; Quinones, Addison; Tan, Jessica; Antonio, Marjorie Justine; Camelo, Felipe; Li, Ting; Nguyen, Stephanie; Hoang, Giang; Nguyen, Kiet; Udupa, Sunag; Sazeides, Christos; Shen, Yao An; Elgogary, Amira; Reyes, Juvenal; Zhao, Liang; Kleensang, Andre; Chaichana, Kaisorn Lee; Hartung, Thomas; Betenbaugh, Michael J.; Marie, Suely K.; Jung, Jin G.; Wang, Tian-Li; Gabrielson, Edward; Le Thi, Quy Hoa.
In: Cell Reports, Vol. 27, No. 2, 09.04.2019, p. 491-501.e6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer
AU - Nguyen, Tu
AU - Kirsch, Brian James
AU - Asaka, Ryoichi
AU - Nabi, Karim
AU - Quinones, Addison
AU - Tan, Jessica
AU - Antonio, Marjorie Justine
AU - Camelo, Felipe
AU - Li, Ting
AU - Nguyen, Stephanie
AU - Hoang, Giang
AU - Nguyen, Kiet
AU - Udupa, Sunag
AU - Sazeides, Christos
AU - Shen, Yao An
AU - Elgogary, Amira
AU - Reyes, Juvenal
AU - Zhao, Liang
AU - Kleensang, Andre
AU - Chaichana, Kaisorn Lee
AU - Hartung, Thomas
AU - Betenbaugh, Michael J.
AU - Marie, Suely K.
AU - Jung, Jin G.
AU - Wang, Tian-Li
AU - Gabrielson, Edward
AU - Le Thi, Quy Hoa
PY - 2019/4/9
Y1 - 2019/4/9
N2 - Nguyen et al. show that NAAG is more abundant in higher grade cancers and a source of glutamate in cancers expressing GCPII, the enzyme that hydrolyzes NAAG to glutamate and NAA. The results suggest that GCPII is a viable target for cancer therapy, either alone or in combination with glutaminase inhibition.
AB - Nguyen et al. show that NAAG is more abundant in higher grade cancers and a source of glutamate in cancers expressing GCPII, the enzyme that hydrolyzes NAAG to glutamate and NAA. The results suggest that GCPII is a viable target for cancer therapy, either alone or in combination with glutaminase inhibition.
KW - GCPII
KW - glutamate carboxypeptidase II
KW - glutamate deprivation
KW - glutamate reservoir
KW - glutaminase inhibitor
KW - metabolomics
KW - N-acetyl-aspartyl-glutamate
KW - NAAG
KW - stable isotope resolved
UR - http://www.scopus.com/inward/record.url?scp=85063761659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063761659&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2019.03.036
DO - 10.1016/j.celrep.2019.03.036
M3 - Article
C2 - 30970252
AN - SCOPUS:85063761659
VL - 27
SP - 491-501.e6
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 2
ER -