Unconscious sedation in children: A prospective multi-arm clinical trial

Loren A. Bauman, Michael L. Cannon, John McCloskey, Sharon Allen, Robert L. James, Joseph R. Tobin, George D. Politis

Research output: Contribution to journalArticlepeer-review


Background: We report the evaluation of six sedative-hypnotic and analgesic combinations administered to children undergoing brief periods of unconscious (or deep) sedation for painful procedures. Methods: In a prospective, open-label, randomized, controlled study of six groups of 27-30 children each, patients were randomly assigned to receive propofol or methohexital for sedation-hypnosis, and one of three incremental doses of fentanyl or remifentanil, respectively. Results: An infusion of methohexital (10 mg·ml-1) combined with remifentanil (6.67 μg·ml-1) provided significantly shorter geometric mean times to initial emergence, to eye-opening and to discharge, and required airway interventions that were not significantly more frequent than all groups sedated with propofol and fentanyl. Conclusions: The combination of methohexital and remifentanil appears to be a satisfactory method for unconcious sedation for short painful procedures in children.

Original languageEnglish (US)
Pages (from-to)674-679
Number of pages6
JournalPaediatric anaesthesia
Issue number8
StatePublished - 2002
Externally publishedYes


  • Analgesia
  • Fentanyl
  • Methohexital
  • Paediatric
  • Propofol
  • Remifentanil
  • Sedation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Anesthesiology and Pain Medicine

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