TY - JOUR
T1 - Uncertainty in mapping malaria epidemiology
T2 - Implications for control
AU - Sullivan, David
N1 - Funding Information:
This work was supported by the Johns Hopkins Malaria Research Institute and by the National Institutes of Health (grant RO1 AI45774-09).
PY - 2010/4
Y1 - 2010/4
N2 - Malaria is a location-specific, dynamic infectious disease transmitted by mosquitoes to humans and is influenced by environmental, vector, parasite, and host factors. The principal purposes of malarial epidemiology are 1) to describe the malarial distribution in space and time along with the physical, biologic, and social etiologic factors and 2) to guide control objectives for either modeling impact or measuring progress of control tactics. Mapping malaria and many of its causative factors has been achieved on many different levels from global distribution to biologic quantitative trait localization in humans, parasites, and mosquitoes. Despite these important achievements, a large degree of uncertainty still exists on the annual burden of malarial cases. Accurate, sensitive detection and treatment of asymptomatic reservoirs important to infectious transmission are additional components necessary for future control measures. Presently spurred by the leadership and funding of Bill and Melinda Gates, the malarial community is developing and implementing plans for elimination of malaria. The challenge for malariologists is to digitally integrate and map epidemiologic factors and intervention measures in space and time to target effective, sustainable control alongside research efforts.
AB - Malaria is a location-specific, dynamic infectious disease transmitted by mosquitoes to humans and is influenced by environmental, vector, parasite, and host factors. The principal purposes of malarial epidemiology are 1) to describe the malarial distribution in space and time along with the physical, biologic, and social etiologic factors and 2) to guide control objectives for either modeling impact or measuring progress of control tactics. Mapping malaria and many of its causative factors has been achieved on many different levels from global distribution to biologic quantitative trait localization in humans, parasites, and mosquitoes. Despite these important achievements, a large degree of uncertainty still exists on the annual burden of malarial cases. Accurate, sensitive detection and treatment of asymptomatic reservoirs important to infectious transmission are additional components necessary for future control measures. Presently spurred by the leadership and funding of Bill and Melinda Gates, the malarial community is developing and implementing plans for elimination of malaria. The challenge for malariologists is to digitally integrate and map epidemiologic factors and intervention measures in space and time to target effective, sustainable control alongside research efforts.
KW - antimalarials
KW - basic reproduction number
KW - epidemiologic factors
KW - epidemiologic measurements
KW - infectious disease incubation period
KW - malaria
KW - malaria, falciparum
KW - malaria, vivax
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U2 - 10.1093/epirev/mxq013
DO - 10.1093/epirev/mxq013
M3 - Review article
C2 - 20581219
AN - SCOPUS:77954993160
SN - 0193-936X
VL - 32
SP - 175
EP - 187
JO - Epidemiologic reviews
JF - Epidemiologic reviews
IS - 1
ER -