Abstract
unc-3 encodes the Caenorhabditis elegans ortholog of the Olf-1/Early B cell factor family of transcription factors, which in vertebrates regulate development and differentiation of B lymphocytes, adipocytes, and cells of the nervous system. unc-3 mutants are uncoordinated in locomotion. Here we show that unc-3 represses a VC-like motor neuron program in the VA and VB motor neurons, which in wild-type animals control backwards and forwards locomotion, respectively. We identify a physical interaction between UNC-3 and the C2H2 zinc finger transcription factor PAG-3, the mammalian homologs of which are coexpressed in olfactory epithelium and hematopoietic cells. Our data explain the locomotory defects of unc-3 mutants and suggest that interactions between unc-3 and pag-3 orthologs in other species may be functionally important.
Original language | English (US) |
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Pages (from-to) | 207-215 |
Number of pages | 9 |
Journal | Developmental biology |
Volume | 323 |
Issue number | 2 |
DOIs | |
State | Published - Nov 15 2008 |
Keywords
- Ebf-1
- Gfi-1
- Motor neuron fate
- olf-1
- pag-3
- unc-3
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology