Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression

Arthur D.P. Mak, Yuen Man Ho, Owen N.W. Leung, Idy Wing Yi Chou, Rashid Lui, Sunny Wong, David K.W. Yeung, Winnie C.W. Chu, Richard Edden, Sandra Chan, Linda Lam, Justin Wu

Research output: Contribution to journalArticlepeer-review

Abstract

Background: GABA-deficit characterizes depression (MDD), which is highly comorbid with Functional Dyspepsia (FD). We examined brain GABA concentrations and resting activities in post-prandial distress subtype FD (FD-PDS) patients with and without MDD. Methods: 24 female age/education-matched FD-PDS with comorbid MDD (FD-PDS-MDD), non-depressed FD-PDS, and healthy controls each were compared on GABA concentrations, resting fMRI (fALFF) in bilateral pregenual anterior cingulate (pgACC), left dorsolateral prefrontal cortex (DLPFC), insula, and somatosensory cortex (SSC). Results: FD-PDS-MDD patients had mild though elevated depressive symptoms. FD-PDS patients had generally mild dyspeptic symptoms. No significant between-group differences in GABA or fALFF were found. No significant correlations were found between GABA and depressive/dyspeptic symptoms after Bonferroni correction. In patients, GABA correlated positively with left insula fALFF (r = 0.38, Bonferroni-corrected p =.03). Conclusion: We did not find altered GABA concentrations or brain resting activity in FD-PDS or its MDD comorbidity. The neurochemical link between MDD and FD remains elusive.

Original languageEnglish (US)
Article number549749
JournalFrontiers in Psychiatry
Volume11
DOIs
StatePublished - Sep 11 2020

Keywords

  • functional dyspepsia
  • GABA
  • magnetic resonance spectroscopy
  • major depressive disorder
  • resting fMRI

ASJC Scopus subject areas

  • Psychiatry and Mental health

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