Ultraviolet light-induced keratinocyte apoptosis: A potential mechanism for the induction of skin lesions and autoantibody production in LE

Research output: Contribution to journalArticle

Abstract

Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease which is characterized clinically by pleiotropy and periodicity. The immune features which accompany the characteristic flares of the disease have strongly suggested that the autoimmune response is driven by self antigen, and is T cell-dependent. These features have prompted the search for potential initiating process(es) which induce the release of self-antigens in a form which causes T cell tolerance to those self molecules to be broken. We review here several recent observations which implicate apoptotic cells as an important potential source of clustered and concentrated autoantigens in SLE, and present our current model whereby the novel autoantigen fragments generated in apoptotic surface blebs initiate and drive the autoimmune response in this disease.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalLupus
Volume6
Issue number2
DOIs
StatePublished - Jan 1 1997

Keywords

  • Apoptosis
  • Autoantibody
  • ICE
  • Keratinocytes
  • Lupus

ASJC Scopus subject areas

  • Rheumatology

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