Ultrastructure of Fos-labeled neurons relating to nociceptive primary afferent and substance P terminals in rat spinal superficial laminae

Y. X. Tao, Z. Q. Zhao

Research output: Contribution to journalArticle

Abstract

The presence of Fos-labeled neurons at ultrastructural level was confirmed in the spinal superficial laminae following an injection of formalin into rat hindpaw in the present study. The Fos-like immunoreactive products were found exclusively in regions associated with the euchromatin in the nuclei of Fos-labeled neurons. By the methods used - of anterograde transport of horseradish peroxidase conjugated to wheat-germ agglutinin and immunocytochemistry - it was observed that some Fos-labeled neuronal bodies received synaptic contacts from, or were apposed directly to, small diameter primary afferent terminals in the spinal superficial laminae. By means of double-labeled immunocytochemistry, a direct apposition was often observed and a synaptic relationship was occasionally found between Fos-labeled neuronal bodies and substance P-like immunoreactive terminals.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalNeuropeptides
Volume31
Issue number4
DOIs
StatePublished - 1997
Externally publishedYes

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Substance P
Neurons
Rats
Immunohistochemistry
Euchromatin
Wheat Germ Agglutinins
Horseradish Peroxidase
Formaldehyde
Injections

ASJC Scopus subject areas

  • Endocrinology
  • Clinical Neurology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Biochemistry

Cite this

Ultrastructure of Fos-labeled neurons relating to nociceptive primary afferent and substance P terminals in rat spinal superficial laminae. / Tao, Y. X.; Zhao, Z. Q.

In: Neuropeptides, Vol. 31, No. 4, 1997, p. 327-332.

Research output: Contribution to journalArticle

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