Ultrastructural investigation of renal biopsies

A discussion of artifacts and special methodology

T. Steen Olsen, Lorraine C Racusen, K. Solez

Research output: Contribution to journalArticle

Abstract

The aim of this presentation is to draw attention to the problems inherent in evaluating the ultrastructure of percutaneous renal biopsies and to discuss some of the special techniques which are useful in this area. It is important to realize that the ultrastructure as it appears in this kind of material does not necessarily reflect conditions in vivo. Comparison with suitable reference material may, however, permit reliable conclusions in terms of pathological diagnosis and pathogenesis. It is advocated that purely qualitative methods, which until now have predominated in ultrastructure work with renal biopsies, be replaced by morphometry and semiquantitative methods when it is possible and practical to do so in any research situation.

Original languageEnglish (US)
Pages (from-to)283-291
Number of pages9
JournalJournal of Electron Microscopy Technique
Volume9
Issue number3
StatePublished - 1988

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pathogenesis
Biopsy
Artifacts
artifacts
methodology
Kidney
Research

ASJC Scopus subject areas

  • Anatomy

Cite this

Ultrastructural investigation of renal biopsies : A discussion of artifacts and special methodology. / Steen Olsen, T.; Racusen, Lorraine C; Solez, K.

In: Journal of Electron Microscopy Technique, Vol. 9, No. 3, 1988, p. 283-291.

Research output: Contribution to journalArticle

Steen Olsen, T. ; Racusen, Lorraine C ; Solez, K. / Ultrastructural investigation of renal biopsies : A discussion of artifacts and special methodology. In: Journal of Electron Microscopy Technique. 1988 ; Vol. 9, No. 3. pp. 283-291.
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