TY - JOUR
T1 - Ultrastructural changes associated with reduced mitochondrial DNA and impaired mitochondrial function in the presence of 2'3'-dideoxycytidine
AU - Lewis, L. D.
AU - Hamzeh, F. M.
AU - Lietman, P. S.
PY - 1992
Y1 - 1992
N2 - Incubation of Molt-4 cells in 4 μM 2'3'-dideoxycytidine did not produce a significant change in the mitochondrial ultrastructure after 4 days; however, by 12 days, the mitochondrial ultrastructure was distorted, with condensed cristae or vacuolization, or both. Concentration-dependent decreases in both cell growth (mean 50% inhibitory concentration, 4.70 ± 0.5 μM) and mitochondrial DNA content (mean 50% inhibitory concentration, 0.46 ± 0.06 μM) occurred after incubation with 2'3'-dideoxycytidine for 4 days.
AB - Incubation of Molt-4 cells in 4 μM 2'3'-dideoxycytidine did not produce a significant change in the mitochondrial ultrastructure after 4 days; however, by 12 days, the mitochondrial ultrastructure was distorted, with condensed cristae or vacuolization, or both. Concentration-dependent decreases in both cell growth (mean 50% inhibitory concentration, 4.70 ± 0.5 μM) and mitochondrial DNA content (mean 50% inhibitory concentration, 0.46 ± 0.06 μM) occurred after incubation with 2'3'-dideoxycytidine for 4 days.
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U2 - 10.1128/AAC.36.9.2061
DO - 10.1128/AAC.36.9.2061
M3 - Comment/debate
C2 - 1329643
AN - SCOPUS:0026686864
SN - 0066-4804
VL - 36
SP - 2061
EP - 2065
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 9
ER -