Ultrastructural changes associated with reduced mitochondrial DNA and impaired mitochondrial function in the presence of 2'3'-dideoxycytidine

L. D. Lewis, F. M. Hamzeh, P. S. Lietman

Research output: Contribution to journalComment/debatepeer-review

Abstract

Incubation of Molt-4 cells in 4 μM 2'3'-dideoxycytidine did not produce a significant change in the mitochondrial ultrastructure after 4 days; however, by 12 days, the mitochondrial ultrastructure was distorted, with condensed cristae or vacuolization, or both. Concentration-dependent decreases in both cell growth (mean 50% inhibitory concentration, 4.70 ± 0.5 μM) and mitochondrial DNA content (mean 50% inhibitory concentration, 0.46 ± 0.06 μM) occurred after incubation with 2'3'-dideoxycytidine for 4 days.

Original languageEnglish (US)
Pages (from-to)2061-2065
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume36
Issue number9
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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