Ultrasound tomosynthesis: A new paradigm for quantitative imaging of the prostate

Fereshteh Aalamifar, Reza Seifabadi, Marcelino Bernardo, Ayele H. Negussie, Baris Turkbey, Maria Merino, Peter Pinto, Arman Rahmim, Bradford J. Wood, Emad Boctor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biopsy under B-mode transrectal ultrasound (TRUS) is the gold standard for prostate cancer diagnosis. However,B-mode US shows only the boundary of the prostate,therefore biopsy is performed in a blind fashion,resulting in many false negatives. Although MRI or TRUS-MRI fusion is more sensitive and specific,it may not be readily available across a broad population,and may be cost prohibitive. In this paper,a limited-angle transmission US methodology is proposed,here called US tomosynthesis (USTS),for prostate imaging. This enables quantitative imaging of the prostate,such as generation of a speed of sound (SOS) map,which theoretically may improve detection,localization,or characterization of cancerous prostate tissue. Prostate USTS can be enabled by adding an abdominal probe aligned with the transrectal probe by utilizing a robotic arm. In this paper,we elaborate proposed methodology; then develop a setup and a technique to enable ex vivo USTS imaging of human prostate immediately after prostatectomy. Custom hardware and software were developed and implemented. Mock ex vivo prostate and lesions were made by filling a mold cavity with water,and adding a plastisol lesion. The time of flights were picked using a proposed center of mass method and corrected manually. The SOS map with a difference expectation-maximization reconstruction performed most accurately,with 2.69 %,0.23 %,0.06 % bias in estimating the SOS of plastisol,water,and mold respectively. Although USTS methodology requires further ex vivo validation,USTS has the potential to open up a new window in quantitative low-cost US imaging of the prostate which may meet a public health need.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2016 - 19th International Conference, Proceedings
PublisherSpringer Verlag
Pages577-584
Number of pages8
Volume9900 LNCS
ISBN (Print)9783319467191
DOIs
Publication statusPublished - 2016
Event1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016 - Athens, Greece
Duration: Oct 21 2016Oct 21 2016

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9900 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016
CountryGreece
CityAthens
Period10/21/1610/21/16

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Keywords

  • Ex vivo
  • Prostate
  • Robotic ultrasound
  • Transmission ultrasound
  • Ultrasound tomography
  • Ultrasound tomosynthesis

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Aalamifar, F., Seifabadi, R., Bernardo, M., Negussie, A. H., Turkbey, B., Merino, M., ... Boctor, E. (2016). Ultrasound tomosynthesis: A new paradigm for quantitative imaging of the prostate. In Medical Image Computing and Computer-Assisted Intervention - MICCAI 2016 - 19th International Conference, Proceedings (Vol. 9900 LNCS, pp. 577-584). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9900 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-319-46720-7_67