Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm

Shelby Kutty; Na Liu; Jia Zhou; Yunbin Xiao; Juefei Wu; David A. Danford; John Lof; Feng Xie; Thomas R. Porter

doi:10.1016/j.jacbts.2017.07.011

Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm

Shelby Kutty, Na Liu, Jia Zhou, Yunbin Xiao, Juefei Wu, David A. Danford, John Lof, Feng Xie, Thomas R. Porter

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available.

Original language	English (US)
Pages (from-to)	748-756
Number of pages	9
Journal	JACC: Basic to Translational Science
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/j.jacbts.2017.07.011
State	Published - Dec 2017
Externally published	Yes

Keywords

N (ω)-nitro-L-arginine methyl ester
catheter-induced vasospasm
microbubble
ultrasound
velocity time integral

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.jacbts.2017.07.011

Cite this

@article{12ae8295a4434d139a9ef65f8a9a8d58,

title = "Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm",

abstract = "Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available.",

keywords = "N (ω)-nitro-L-arginine methyl ester, catheter-induced vasospasm, microbubble, ultrasound, velocity time integral",

author = "Shelby Kutty and Na Liu and Jia Zhou and Yunbin Xiao and Juefei Wu and Danford, {David A.} and John Lof and Feng Xie and Porter, {Thomas R.}",

note = "Funding Information: Dr. Kutty is supported by the American Heart Association and the National Institute of Child Health and Development. Dr. Porter is supported by the Theodore F Hubbard Foundation. Funding sources were not involved in data collection, data analysis, or manuscript drafting. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. All institutional and national guidelines for the care and use of laboratory animals were followed and approved by the appropriate institutional committees. Drs. Kutty and Liu contributed equally to this work. Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = dec,

doi = "10.1016/j.jacbts.2017.07.011",

language = "English (US)",

volume = "2",

pages = "748--756",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm

AU - Kutty, Shelby

AU - Liu, Na

AU - Zhou, Jia

AU - Xiao, Yunbin

AU - Wu, Juefei

AU - Danford, David A.

AU - Lof, John

AU - Xie, Feng

AU - Porter, Thomas R.

N1 - Funding Information: Dr. Kutty is supported by the American Heart Association and the National Institute of Child Health and Development. Dr. Porter is supported by the Theodore F Hubbard Foundation. Funding sources were not involved in data collection, data analysis, or manuscript drafting. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. All institutional and national guidelines for the care and use of laboratory animals were followed and approved by the appropriate institutional committees. Drs. Kutty and Liu contributed equally to this work. Publisher Copyright: © 2017 The Authors

PY - 2017/12

Y1 - 2017/12

N2 - Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available.

AB - Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available.

KW - N (ω)-nitro-L-arginine methyl ester

KW - catheter-induced vasospasm

KW - microbubble

KW - ultrasound

KW - velocity time integral

UR - http://www.scopus.com/inward/record.url?scp=85040785848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040785848&partnerID=8YFLogxK

U2 - 10.1016/j.jacbts.2017.07.011

DO - 10.1016/j.jacbts.2017.07.011

M3 - Article

AN - SCOPUS:85040785848

SN - 2452-302X

VL - 2

SP - 748

EP - 756

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 6

ER -

Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this