Ultrasensitive enzymatic radioimmunoassay: Application to detection of cholera toxin and rotavirus

C. C. Harris, R. H. Yolken, H. Krokan, I. C. Hsu

Research output: Contribution to journalArticle

Abstract

Rotavirus and enterotoxin-producing bacteria are major causes of diarrheal disease in humans. A method of rapid diagnosis, ultrasensitive enzymatic radioimmunoassay, has been developed to quantitatively detect cholera toxin and rotavirus. The method uses features of both enzyme-linked immunosorbent assay and radioimmunoassay; however, the sensitivity of the assay is 100- to 1000-fold more sensitive than the two parent assays. Ultrasensitive enzymatic radioimmunoassay should also be useful in measuring other biologically important agents such as drugs and hormones.

Original languageEnglish (US)
Pages (from-to)5336-5339
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number10
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • General

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