Ulcerated atherosclerotic plaques in the thoracic aorta are associated with cryptogenic stroke: A multiplane transesophageal echocardiographic study

David A. Stone, Mary W. Hawke, Marian LaMonte, Steven J. Kittner, Joseph Acosta, Mary Corretti, Cindy Sample, Thomas R. Price, Gary D. Plotnick

Research output: Contribution to journalArticle

Abstract

Atherosclerotic plaque ulcers ≥2 mm in depth and width in the thoracic aorta have been implicated by autopsy study as a cause of unexplained or cryptogenic ischemic strokes. Transesophageal echocardiography (TEE) allows visualization of complex atherosclerotic lesions of the thoracic aorta. We compared the prevalence of thoracic aorta ulcerated plaques (ulcers ≥2 mm in both depth and width) in three age-matched groups undergoing multiplane TEE: group 1, 23 patients with cryptogenic ischemic stroke; group 2, 26 patients with known-cause strokes; and group 3, 57 control patients without strokes. TEEs were interpreted in a blinded fashion. Ulcerated plaques were found in 9 (39%) group 1 patients but in only 2 (8%) group 2 patients and in only 4 (7%) group 3 patients (p <0.001). There was an association between advancing age and the presence of ulcerated plaques (p <0.02). We conclude that ulcerated atherosclerotic plaques in the thoracic aorta are associated with cryptogenic ischemic stroke and should be considered a potential source of cerebral emboli.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalAmerican Heart Journal
Volume130
Issue number1
DOIs
StatePublished - 1995

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Atherosclerotic Plaques
Thoracic Aorta
Stroke
Transesophageal Echocardiography
Ulcer
Intracranial Embolism
Autopsy
Research Design
Age Groups

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ulcerated atherosclerotic plaques in the thoracic aorta are associated with cryptogenic stroke : A multiplane transesophageal echocardiographic study. / Stone, David A.; Hawke, Mary W.; LaMonte, Marian; Kittner, Steven J.; Acosta, Joseph; Corretti, Mary; Sample, Cindy; Price, Thomas R.; Plotnick, Gary D.

In: American Heart Journal, Vol. 130, No. 1, 1995, p. 105-108.

Research output: Contribution to journalArticle

Stone, David A. ; Hawke, Mary W. ; LaMonte, Marian ; Kittner, Steven J. ; Acosta, Joseph ; Corretti, Mary ; Sample, Cindy ; Price, Thomas R. ; Plotnick, Gary D. / Ulcerated atherosclerotic plaques in the thoracic aorta are associated with cryptogenic stroke : A multiplane transesophageal echocardiographic study. In: American Heart Journal. 1995 ; Vol. 130, No. 1. pp. 105-108.
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AU - Price, Thomas R.

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