Ubiquity of the repetitive epitope of the CS protein in different isolates of human malaria parasites

F. Zavala, A. Masuda, P. M. Graves, V. Nussenzweig, R. S. Nussenzweig

Research output: Contribution to journalArticlepeer-review

Abstract

Sporozoites of the human malaria Plasmodium falciparum and Plasmodium vivax obtained from a large number of endemic areas were screened with species-specific monoclonal antibodies that recognize the repeated epitopes of the respective circumsporozoite (CS) proteins. By using a two-site immunoradiometric assay, it was determined that all the parasite isolates of a given species react with a single monoclonal antibody, indicating the presence of a common repeated epitope. Polyacrylamide gel electrophoresis, followed by Western blot, showed that the CS proteins of the various isolates differed in their apparent m.w.

Original languageEnglish (US)
Pages (from-to)2790-2793
Number of pages4
JournalJournal of Immunology
Volume135
Issue number4
StatePublished - Dec 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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